Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi Arabia.
College of Health Sciences, Applied Medical Sciences Department, PAAET, Safat, Kuwait.
Pharm Biol. 2022 Dec;60(1):1137-1147. doi: 10.1080/13880209.2022.2079678.
Camel milk is used in traditional medicine to treat diabetes mellitus hypertension and other metabolic disorders.
This study evaluated the antisteatotic and antihypertensive effects of camel milk protein hydrolysate (CMH) in high fructose (HF)-fed rats and compared it with the effects afforded by the intact camel milk protein extract (ICM).
Adult male Wistar rats were divided into 6 groups ( = 8 each) as 1) control, 2) ICM (1000 mg/kg), 3) CMH (1000 mg/kg), 4) HF (15% in drinking water), 5) HF (15%) + ICM (1000 mg/kg), and 6) HF (15%) + CMH (1000 mg/kg). All treatments were given orally for 21 weeks, daily.
Both ICM and CMH reduced fasting glucose and insulin levels, serum and hepatic levels of cholesterol and triglycerides, and serum levels of ALT and AST, angiotensin II, ACE, endothelin-1, and uric acid in HF-fed rats. In addition, both ICM and CMH reduced hepatic fat deposition in the hepatocytes and reduced hepatocyte damage. This was associated with an increase in the hepatic activity of AMPK, higher PPARα mRNA, reduced expression of fructokinase C, SREBP1, SREBP2, fatty acid synthase, and HMG-CoA-reductase. Both treatments lowered systolic and diastolic blood pressure. However, the effects of CMH on all these parameters were greater as compared to ICM.
The findings of this study encourage the use of CMH in a large-scale population and clinical studies to treat metabolic steatosis and hypertension.
骆驼奶在传统医学中被用于治疗糖尿病、高血压和其他代谢紊乱。
本研究评估了骆驼乳蛋白水解物（CMH）在高果糖（HF）喂养大鼠中的抗脂肪变性和降压作用，并将其与完整骆驼乳蛋白提取物（ICM）的作用进行了比较。
成年雄性 Wistar 大鼠分为 6 组（每组 8 只）：1）对照组，2）ICM（1000mg/kg），3）CMH（1000mg/kg），4）HF（饮用水中 15%），5）HF（15%）+ICM（1000mg/kg），和 6）HF（15%）+CMH（1000mg/kg）。所有治疗均连续 21 周，每日口服给予。
ICM 和 CMH 均降低了 HF 喂养大鼠的空腹血糖和胰岛素水平、血清和肝脏胆固醇和甘油三酯水平以及血清丙氨酸转氨酶和天冬氨酸转氨酶、血管紧张素 II、ACE、内皮素-1 和尿酸水平。此外，ICM 和 CMH 均减少了肝脂肪在肝细胞中的沉积，并减轻了肝细胞损伤。这与 AMPK 肝活性增加、PPARαmRNA 升高、果糖激酶 C、SREBP1、SREBP2、脂肪酸合酶和 HMG-CoA 还原酶表达降低有关。两种治疗均降低了收缩压和舒张压。然而，与 ICM 相比，CMH 对所有这些参数的作用更大。
本研究的结果鼓励在大规模人群和临床研究中使用 CMH 来治疗代谢性脂肪变性和高血压。
