Department of Anesthesiology and Critical Care, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel.
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL, USA.
Transl Psychiatry. 2022 Jun 7;12(1):239. doi: 10.1038/s41398-022-01991-1.
Traumatic brain injury (TBI) affects millions of people worldwide, many of whom are affected with post-TBI mood disorders or behavioral changes, including aggression or social withdrawal. Diminished functionality can persist for decades after TBI and delay rehabilitation and resumption of employment. It has been established that there is a relationship between these mental disorders and brain injury. However, the etiology and causal relationships behind these conditions are poorly understood. Rodent models provide a helpful tool for researching mood disorders and social impairment due to their natural tendencies to form social hierarchies. Here, we present a rat model of mental complications after TBI using a suite of behavioral tests to examine the causal relationships between changes in social behavior, including aggressive, hierarchical, depressive, and anxious behavior. For this purpose, we used multivariate analysis to identify causal relationships between the above post-TBI psychiatric sequelae. We performed statistical analysis using principal component analysis, discriminant analysis, and correlation analysis, and built a model to predict dominant-submissive behavior based on the behavioral tests. This model displayed a predictive accuracy of 93.3% for determining dominant-submissive behavior in experimental groups. Machine learning algorithms determined that in rats, aggression is not a principal prognostic factor for dominant-submissive behavior. Alternatively, dominant-submissive behavior is determined solely by the rats' depressive-anxious state and exploratory activity. We expect the causal approach used in this study will guide future studies into mood conditions and behavioral changes following TBI.
创伤性脑损伤 (TBI) 影响着全球数百万人，其中许多人患有创伤后情绪障碍或行为改变，包括攻击性或社交退缩。TBI 后功能障碍可持续数十年，从而延迟康复和重新就业。已经确定这些精神障碍与脑损伤之间存在关系。然而，这些疾病的病因和因果关系尚不清楚。由于啮齿动物具有形成社会等级的自然倾向，因此它们为研究情绪障碍和社交障碍提供了有用的工具。在这里，我们使用一系列行为测试介绍了一种 TBI 后精神并发症的大鼠模型，以研究社交行为变化（包括攻击性、等级性、抑郁性和焦虑性行为）之间的因果关系。为此，我们使用多元分析来确定上述创伤后精神后遗症之间的因果关系。我们使用主成分分析、判别分析和相关分析进行统计分析，并根据行为测试构建了一个预测优势-劣势行为的模型。该模型显示，在实验组中，预测主导-从属行为的准确率为 93.3%。机器学习算法确定，在大鼠中，攻击性不是主导-从属行为的主要预后因素。相反，主导-从属行为仅由大鼠的抑郁-焦虑状态和探索性活动决定。我们希望本研究中使用的因果方法将指导未来对 TBI 后情绪状况和行为变化的研究。
