Karagezian K G, Ovsepian L M, Adonts K G
Vopr Med Khim. 1990 Mar-Apr;36(2):10-2.
Total content of phospholipids and their individual components were distinctly increased in microsomal, mitochondrial fractions and in inner mitochondrial membrane of rat hepatocytes under conditions of alloxan diabetes. The concentrations of these substances were decreased in outer mitochondrial membrane. Activation of lipid free-radical oxidation was found in all the membrane structures studied. In microsomal fraction of hepatocytes the rate of hydroxylation reaction was decreased, accompanied by a decrease in content of cytochromes b5 and P-450.
在四氧嘧啶糖尿病条件下，大鼠肝细胞微粒体、线粒体组分及线粒体内膜中磷脂及其各组分的总含量明显增加。这些物质在外膜中的浓度降低。在所研究的所有膜结构中均发现脂质自由基氧化被激活。在肝细胞微粒体组分中，羟化反应速率降低，同时细胞色素b5和P - 450含量减少。
