[Phospholipid-phospholipid relations and changes of free radical lipid oxidation in biological membranes during alloxan diabetes].

Quantitative and qualitative composition of phospholipids as well as lipid peroxidation were studied in outer and inner mitochondrial membranes and microsomal fraction from rat liver tissue under conditions of alloxane diabetes. In the diabetes amount of phospholipids, mainly cardiolipins and phosphatidylethanolamines, was increased in the inner and decreased in the outer mitochondrial membranes. Phosphatidylcholines and phosphatidylserines were increased in microsomal fraction. At the same time, lipid peroxidation was activated both in ascorbate- and NADPH-dependent systems of oxidation. These data suggest that lipid peroxidation affects the composition of mitochondrial membranes either by means of removing of the substances from membranes or via their redistribution between the subcellular fractions.