Portier C J, Dinse G E
Biometrics. 1987 Mar;43(1):107-14.
This paper addresses the problem of comparing treatment groups with respect to the rate of tumor development for animals in a survival experiment with some serial sacrifices. The analysis specifies a parametric model for the tumor incidence function, but places no parametric restrictions on the death rates. The procedure is feasible with as few as two sacrifice times and requires no individual data on cause of death. Other diseases need not act independently of the tumor of interest, nor are any restrictions imposed on tumor lethality or the relationship between the onset and death times for tumor-bearing animals. The proposed methods are illustrated with some survival/sacrifice data.
本文探讨了在一项有多次连续处死的生存实验中，比较各治疗组动物肿瘤发生速率的问题。分析为肿瘤发生率函数指定了一个参数模型，但对死亡率未施加参数限制。该程序在仅有两个处死时间点的情况下也是可行的，并且不需要关于死亡原因的个体数据。其他疾病无需独立于所关注的肿瘤起作用，对于肿瘤致死性或患肿瘤动物发病与死亡时间之间的关系也不施加任何限制。文中用一些生存/处死数据对所提出的方法进行了说明。
