与中西部大型医疗保健系统中 COVID-19 突破性感染相关的因素：对脆弱医疗保健人员的影响。
Factors Associated With COVID-19 Breakthrough Infections in Large Midwestern Healthcare System: Implications for Vulnerable Healthcare Personnel.
机构信息
From the Advocate Aurora Health, Downers Grove, Illinois (Rivelli, Fitzpatrick, Copeland, Richards); Advocate Aurora Research Institute, Milwaukee, Wisconsin (Rivelli, Fitzpatrick); and ACL Laboratories, Milwaukee, Wisconsin (Copeland).
出版信息
J Occup Environ Med. 2022 Aug 1;64(8):635-641. doi: 10.1097/JOM.0000000000002576. Epub 2022 Jun 9.
OBJECTIVE
The aim of the study is to identify factors associated with breakthrough infection among a cohort of Midwestern healthcare personnel (HCP).
METHODS
SARS-CoV-2-positive test results between March 1, 2020, and July 31, 2021, were collected from electronic medical records of HCP to identify breakthrough infections.
RESULTS
Healthcare personnel who were younger than 35 years, received the Pfizer vaccine, and worked in COVID clinical units had greater adjusted odds of breakthrough infection. COVID infection before full vaccination was associated with reduced odds of breakthrough infection.
CONCLUSIONS
Our study concluded that the most vulnerable HCP are younger, working in COVID-19 clinical units, and received Pfizer-BioNTech primary series vaccines. Healthcare personnel who had COVID before vaccination were at reduced risk of breakthrough infection, indicating that supplemental immunity could better protect at-risk HCP groups.
目的
本研究旨在确定中西部医护人员（HCP）队列中与突破性感染相关的因素。
方法
从电子病历中收集 2020 年 3 月 1 日至 2021 年 7 月 31 日期间 SARS-CoV-2 阳性检测结果，以确定突破性感染。
结果
年龄小于 35 岁、接种辉瑞疫苗和在 COVID 临床科室工作的医护人员发生突破性感染的调整后比值比更高。完全接种疫苗前感染 COVID 与突破性感染的几率降低有关。
结论
本研究得出的结论是，最脆弱的 HCP 是年龄较小、在 COVID-19 临床科室工作以及接种辉瑞-生物技术公司初级系列疫苗的医护人员。接种疫苗前感染 COVID 的医护人员发生突破性感染的风险降低，表明补充免疫可以更好地保护高危 HCP 群体。
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