Morshedzadeh Nava, Ahmadi Amirhossein Ramezani, Tahmasebi Raziye, Tavasolian Ronia, Heshmati Javad, Rahimlou Mehran
Department of Nutrition, Faculty of Public Health, Kerman University of Medical Sciences, Kerman, Iran.
Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Diabetes Metab Disord. 2022 Jan 11;21(1):979-990. doi: 10.1007/s40200-021-00952-7. eCollection 2022 Jun.
Various studies have evaluated the effects of low-carbohydrate diet (LCD) on serum concentrations of adipokines. Although the association between LCD and serum levels of leptin and adiponectin has been studied extensively, the results were not consistent.
The purpose of this study was to systematically evaluate the effect of LCD on serum levels of leptin and adiponectin.
Electronic databases were retrieved in PubMed, Embase, Scopus and Web of Science to search relevant publications. Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by the random-effect model. Cochrane Q test and I statistic were used to test heterogeneity. Subgroup analysis and meta-regression were applied to assess possible sources of heterogeneity.
A total of thirty-five articles were included in final analysis. Meta-analysis results revealed no statistical association between LCD and adiponectin concentration (WMD: 0.32 ng/ml, 95% CI: - 0.02, 0.66, p=0.062). Subgroup analysis showed that LCD increased adiponectin concentration in subjects under 45 years old and in studies with long term duration intervention. Also, did not observe a significant effect from the LCD on serum concentration of leptin (WMD: - 0.77 ng/ml, 95% CI: -3.15, 1.61, P=0.409). Subgroup analysis did not show any new information. The results of this study did not support the evidence for the positive effects of LCD on serum leptin and adiponectin levels.
多项研究评估了低碳水化合物饮食（LCD）对脂肪因子血清浓度的影响。尽管已广泛研究了LCD与瘦素和脂联素血清水平之间的关联，但结果并不一致。
本研究的目的是系统评估LCD对瘦素和脂联素血清水平的影响。
在PubMed、Embase、Scopus和Web of Science中检索电子数据库以搜索相关出版物。采用随机效应模型计算合并标准平均差（SMD）及其95%置信区间（CI）。使用Cochrane Q检验和I统计量检验异质性。应用亚组分析和Meta回归评估可能的异质性来源。
最终分析共纳入35篇文章。Meta分析结果显示，LCD与脂联素浓度之间无统计学关联（加权均数差：0.32 ng/ml，95%CI：-0.02，0.66，P = 0.062）。亚组分析表明，LCD可提高45岁以下受试者以及长期干预研究中的脂联素浓度。此外，未观察到LCD对瘦素血清浓度有显著影响（加权均数差：-0.77 ng/ml，95%CI：-3.15，1.61，P = 0.409）。亚组分析未显示任何新信息。本研究结果不支持LCD对血清瘦素和脂联素水平有积极影响的证据。
