Zhi Hong-Fang, Yang Liu-Feng, Ge Jing, Yang Xuan-Tao
Department of Pathology, Kunming Kingmed Institute for Clinical Laboratory, Kunming, 650506, People's Republic of China.
Department of Gynecology, The First People's Hospital of Yunnan Province/Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650032, People's Republic of China.
Infect Drug Resist. 2022 Jun 1;15:2843-2851. doi: 10.2147/IDR.S364763. eCollection 2022.
This study aimed to analyze the status of human papillomavirus (HPV) infections in women in Yunnan in the south of China and their correlation with the grade of cervical intraepithelial neoplasia (CIN).
A total of 281 patients with CIN and HPV infection, diagnosed at Kunming Kingmed Institute for Clinical Laboratory between January 2019 and June 2021, were enrolled as the subjects of the study and underwent HPV genotyping and cervical histopathology.
The mean age of the 281 patients was 42.3 years, and the median age was 42 years. There were 79 patients in the low-grade squamous intraepithelial lesion (LSIL) group, and 202 patients in the high-grade squamous intraepithelial lesion (HSIL) group. The proportion of 30-45 years old in HSIL group was 58%. Overall, single infections accounted for 76%, and HR-HPV infections accounted for 90.1%. The most common HR-HPV subtypes in the two CIN groups were almost the same, including HPV16, HPV58 and HPV52. The most common LR-HPV subtype in the two CIN groups was HPV43. There were no significant differences in ethnic and single or multiple infection rates among different CIN groups. Single infection of HPV43 and HPV81 was found in minority HSIL patients.
HPV infection in Yunnan was dominated by single infection and HR-HPV. Patients aged 30 to 45 years were in the high incidence of HSIL, and the most common HR-HPV subtypes were HPV16, HPV58, and HPV52. Single LR-HPV infection exists in minority HSIL patients.
本研究旨在分析中国南部云南省女性人乳头瘤病毒（HPV）感染状况及其与宫颈上皮内瘤变（CIN）分级的相关性。
选取2019年1月至2021年6月在昆明金域临床检验中心诊断为CIN且合并HPV感染的281例患者作为研究对象，进行HPV基因分型及宫颈组织病理学检查。
281例患者的平均年龄为42.3岁，中位年龄为42岁。低级别鳞状上皮内病变（LSIL）组79例，高级别鳞状上皮内病变（HSIL）组202例。HSIL组中30 - 45岁的比例为58%。总体上，单一感染占76%，高危型HPV（HR-HPV）感染占90.1%。两个CIN组中最常见的HR-HPV亚型基本相同，包括HPV16、HPV58和HPV52。两个CIN组中最常见的低危型HPV（LR-HPV）亚型为HPV43。不同CIN组在民族、单一或多重感染率方面无显著差异。少数HSIL患者中发现HPV43和HPV81单一感染。
云南HPV感染以单一感染和HR-HPV为主。30至45岁患者HSIL发病率高，最常见的HR-HPV亚型为HPV16、HPV58和HPV52。少数HSIL患者存在单一LR-HPV感染。
