不明原发神经内分泌肿瘤继发胸段哑铃状脊柱转移瘤：病例报告及文献复习
Thoracic dumbbell spinal metastasis secondary to neuroendocrine tumor of unknown origin: Case report and literature review.
作者信息
Costanzo Roberta, Porzio Massimiliano, Gerardi Rosa Maria, Napolitano Caterina, Bellavia Sandro, Pino Maria Angela, Bencivinni Francesco, Banco Maria Aurelia, Maugeri Rosario, Iacopino Domenico Gerardo, Florena Ada Maria
机构信息
Neurosurgical Clinic AOUP "Paolo Giaccone", Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, Palermo.
Department of Sciences for Promotion of Health and Mother and Child Care, Anatomic Pathology, University of Palermo, Unit of Pathology.
出版信息
Surg Neurol Int. 2022 May 13;13:199. doi: 10.25259/SNI_341_2022. eCollection 2022.
BACKGROUND
Dumbbell tumors are typically benign schwannomas, neurofibromas, and meningiomas and only rarely there are malignant variants of these lesions or other malignant histotypes. Here, a 34-year-old male presented with a thoracic spinal dumbbell metastatic neuroendocrine carcinoma of unknown primary origin.
CASE DESCRIPTION
A 34-year-old male presented with 2 months of thoracic pain and progressive mid thoracic sensory loss. A post contrast thoracic MRI showed a dumbbell tumor localized between the T7 and T9 levels with extension laterally into the T7-T8 and T8-T9 foramina. The patient underwent a laminectomy for tumor resection following which his pain and gait improved. Histopathologically, the tumor demonstrated multiple rounded small cells with a Ki67 level around 30%, suggesting a malignant metastatic neuroendocrine tumor of unknown etiology.
CONCLUSION
We successfully treated a 34-year-old male with a T7-T9 malignant spinal dumbbell neuroendocrine tumor of unknown etiology utilizing a decompressive laminectomy.
背景
哑铃形肿瘤通常为良性神经鞘瘤、神经纤维瘤和脑膜瘤，这些病变的恶性变体或其他恶性组织学类型极为罕见。在此，一名34岁男性患者出现了原发灶不明的胸段脊柱哑铃形转移性神经内分泌癌。
病例描述
一名34岁男性患者出现了2个月的胸痛和胸段中部进行性感觉丧失。增强后的胸部MRI显示一个哑铃形肿瘤位于T7和T9水平之间，向外侧延伸至T7-T8和T8-T9椎间孔。患者接受了椎板切除术以切除肿瘤，术后其疼痛和步态得到改善。组织病理学检查显示，肿瘤由多个圆形小细胞组成，Ki67水平约为30%，提示为病因不明的恶性转移性神经内分泌肿瘤。
结论
我们通过减压性椎板切除术成功治疗了一名患有T7-T9原发灶不明的恶性脊柱哑铃形神经内分泌肿瘤的34岁男性患者。
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