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化疗放疗有效治疗转移性椎体神经内分泌肿瘤术后早期复发

Early post-surgical recurrence of metastatic vertebral neuro-endocrine tumour treated effectively with chemo-radiotherapy.

作者信息

Kaliya-Perumal Arun-Kumar, Tan Mark, Tee Seh Wee, Achudan Shaam, Yap Wai Ming, Oh Jacob Yoong Leong

机构信息

Department of Orthopaedic Surgery, Spine Division, Tan Tock Seng Hospital, Singapore - Department of Orthopaedic Surgery, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur, Tamil Nadu, India.

Department of Orthopaedic Surgery, Spine Division, Tan Tock Seng Hospital, Singapore.

出版信息

Biomedicine (Taipei). 2019 Mar;9(1):5. doi: 10.1051/bmdcn/2019090105. Epub 2019 Feb 22.

DOI:10.1051/bmdcn/2019090105
PMID:30794152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6385615/
Abstract

Spinal metastasis of neuro-endocrine tumours (NETs) usually arise from a primary in the lung. We encountered such a patient with NET metastasis to T6 vertebra causing severe cord compression. Considering the neurological status, immediate decompression surgery along with T3-T8 posterior stabilization was done. Early recurrence of the tumour causing near total obliteration of the spinal canal leading to significant neurological compromise was noted within one month of surgery. A second surgery at this stage was avoided due to the risk involved and concurrent chemo-radiotherapy was initiated. The tumour was sensitive to chemo-radiotherapy and rapid resolution was noted on subsequent follow-up visits. With appropriate rehabilitation, patient regained full power to become ambulant with support. This case report highlights a rare, early and aggressive recurrence of metastatic vertebral NET following index surgery which was effectively managed with chemo-radiotherapy.

摘要

神经内分泌肿瘤（NETs）的脊柱转移通常源于肺部的原发性肿瘤。我们遇到了这样一位患者，其NET转移至T6椎体，导致严重的脊髓压迫。考虑到神经状况，立即进行了减压手术，并同时进行了T3 - T8后路固定。术后一个月内，发现肿瘤早期复发，几乎完全阻塞了椎管，导致严重的神经功能损害。由于手术风险，此阶段避免了二次手术，并开始进行同步放化疗。肿瘤对放化疗敏感，在随后的随访中可见迅速缓解。经过适当的康复治疗，患者恢复了全部力量，在辅助下能够行走。本病例报告强调了转移性椎体NET在初次手术后罕见、早期且侵袭性的复发情况，通过放化疗得到了有效控制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0380/6385615/3cfe4d685959/bmdcn-9-5-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0380/6385615/1a64f9c3e2ad/bmdcn-9-5-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0380/6385615/25567f5349c6/bmdcn-9-5-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0380/6385615/39a2208e0fca/bmdcn-9-5-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0380/6385615/b254ab77f354/bmdcn-9-5-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0380/6385615/76f8343eb4ae/bmdcn-9-5-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0380/6385615/06014f6abeb9/bmdcn-9-5-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0380/6385615/3cfe4d685959/bmdcn-9-5-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0380/6385615/1a64f9c3e2ad/bmdcn-9-5-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0380/6385615/25567f5349c6/bmdcn-9-5-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0380/6385615/39a2208e0fca/bmdcn-9-5-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0380/6385615/b254ab77f354/bmdcn-9-5-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0380/6385615/76f8343eb4ae/bmdcn-9-5-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0380/6385615/06014f6abeb9/bmdcn-9-5-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0380/6385615/3cfe4d685959/bmdcn-9-5-fig7.jpg

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