College of Veterinary Medicine, St Paul, MN, USA.
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.
J Vet Diagn Invest. 2022 Jul;34(4):602-611. doi: 10.1177/10406387221099538. Epub 2022 Jun 8.
Porcine circovirus 3 (PCV3) is widespread in pigs worldwide. Diverse clinical signs and lesions have been associated with PCV3, but the role of PCV3 as a cause of disease in swine remains unclear. We investigated the association of PCV3 with clinical signs and histologic lesions in 730 diagnostic swine cases between February 2016 and January 2018. The cases contained 2,177 samples submitted from 474 sites located in 21 states in the United States. PCR assay results were positive for PCV3 for 577 of 2,177 (27%) samples, 255 of 730 (35%) cases, 181 of 474 (38%) sites, and 17 of 21 (81%) states. We detected PCV3 in 19 of 28 specimen types and in pigs of all ages and clinical presentations, including healthy pigs, with the highest detection rate in adult pigs. PCV3 detection was not associated with respiratory, gastrointestinal, or CNS signs, weight loss, or sudden death. Of 58 types of histologic lesions evaluated, PCV3 detection was associated with myocarditis, cardiac vasculitis, and interstitial pneumonia in growing pigs. A high PCV3 detection rate was observed in aborted fetuses.
猪圆环病毒 3 型（PCV3）在全球范围内广泛存在于猪群中。多种临床症状和病变与 PCV3 相关，但 PCV3 作为猪病病因的作用仍不清楚。我们调查了 PCV3 与 2016 年 2 月至 2018 年 1 月期间 730 例诊断性猪病例的临床症状和组织学病变之间的关系。这些病例包含了来自美国 21 个州的 474 个地点的 2177 个样本。PCR 检测结果显示，2177 个样本中有 577 个（27%）、730 个病例中有 255 个（35%）、474 个地点中有 181 个（38%）和 21 个州中有 17 个（81%）为 PCV3 阳性。我们在 28 种标本类型中的 19 种中检测到了 PCV3，在所有年龄和临床表现的猪中都检测到了 PCV3，包括健康猪，成年猪的检出率最高。PCV3 的检测与呼吸道、胃肠道或中枢神经系统症状、体重减轻或突然死亡无关。在评估的 58 种组织学病变类型中，PCV3 的检测与生长猪的心肌炎、心脏血管炎和间质性肺炎有关。流产胎儿中 PCV3 的检出率很高。
