Marks J G, Thor D E, Lowe R S
Arch Dermatol. 1978 Sep;114(9):1336-9.
Darier's disease is frequently complicated by bacterial skin infections and occasionally by Kaposi's varicelliform eruption. Postulating that defective host immunologic competence might explain these infections, humoral and cell-mediated immunity (CMI) were evaluated in four patients. Humoral immunity was normal as demonstrated by quantitative immunoglobulins, isohemagglutinins, direct skin immunofluorescence, and B-cell counts. The CMI was evaluated by standard delayed type hypersensitivity skin tests, T-cell counts, lymphocyte transformation assays, macrophage inhibition factor (MIF) assays, and skin windows. Blunted lymphocyte blastogenesis, MIF, and skin window response indicated depressed CMI. Polymorphonuclear leukocyte chemotaxis and phagocytosis were normal.
毛囊角化病常并发细菌性皮肤感染，偶尔还会出现水痘样疹（卡波西水痘样疹）。鉴于宿主免疫功能缺陷可能是这些感染的原因，对4例患者的体液免疫和细胞介导免疫（CMI）进行了评估。通过定量免疫球蛋白、同种血凝素、直接皮肤免疫荧光和B细胞计数证明体液免疫正常。CMI通过标准迟发型超敏皮肤试验、T细胞计数、淋巴细胞转化试验、巨噬细胞抑制因子（MIF）试验和皮肤窗试验进行评估。淋巴细胞增殖反应、MIF和皮肤窗反应减弱表明CMI降低。多形核白细胞趋化性和吞噬作用正常。
