Luquetti A, Newton C A, Webster A D
Allergol Immunopathol (Madr). 1981 Jul-Aug;9(4):295-306.
In vivo and in vitro T lymphocyte function was studied in 64 patients with X-linked and common "variable" primary hypogammaglobulinaemia. Lymphopenia, splenomegaly, depressed in vitro lymphocyte transformation to mitogens and failure to manifest delayed hypersensitivity skin reactions occurred frequently in the common "variable" group, particularly those with adult onset disease. However, relative circulating T lymphocyte numbers and in vitro lymphocyte transformation in a mixed lymphocyte reaction with the CLA4 lymphoid cell line were normal. Antibody mediated and PHA induced lymphocytotoxicity were also normal. These findings indicate the presence of a generalised lymphocyte defect which is selective for certain T lymphocyte functions. Despite these apparent T lymphocyte defect, none of the patients suffered from the unusual opportunistic parasitic, viral or fungal infections which tend to occur in infants with severe primary defects of both T and B lymphocytes.
对64例X连锁和常见“变异型”原发性低丙种球蛋白血症患者的体内和体外T淋巴细胞功能进行了研究。淋巴细胞减少、脾肿大、体外淋巴细胞对有丝分裂原的转化受抑制以及迟发性超敏皮肤反应未出现，在常见“变异型”组中频繁发生，尤其是那些成年发病的患者。然而，相对循环T淋巴细胞数量以及与CLA4淋巴细胞系进行混合淋巴细胞反应时的体外淋巴细胞转化是正常的。抗体介导的和PHA诱导的淋巴细胞毒性也是正常的。这些发现表明存在一种普遍的淋巴细胞缺陷，该缺陷对某些T淋巴细胞功能具有选择性。尽管存在这些明显的T淋巴细胞缺陷，但没有患者患有在T和B淋巴细胞均有严重原发性缺陷的婴儿中易出现的不寻常的机会性寄生虫、病毒或真菌感染。
