Vedtofte P, Joensen H D, Dabelsteen E, Veien N
Acta Derm Venereol. 1978;58(1):51-5.
Skin biopsies from 6 patients, and biopsies of the palatal mucosa of 4 of these patients with dyskeratosis follicularis (DF) (Dariers disease) were examined for in vivo bound antibodies by means of a direct immunofluorescence (IF) technique. Antibodies located in the intercellular substance of the epidermis were found in the skin lesions of all patients. Immunoglobulins of the classes IgG, IgA and IgM as well as C3 were found in all lesions. No antibodies reacting with the palatal mucosa were found. Sera from 6 patients with DF and 10 control persons were tested by an indirect IF technique for circulating antibodies. Guinea pig lip and normal oral mucosa and skin were used as antigens. All patients sera and one control serum reacted with the basal cell of the guinea pig lip. Three DF sera--but no control sera--reacted with the basal cells of human oral mucosa. None of the sera reacted with human skin.
对6例患者的皮肤活检样本，以及其中4例毛囊角化不良（DF）（达里埃病）患者的腭黏膜活检样本，采用直接免疫荧光（IF）技术检测体内结合抗体。在所有患者的皮肤病变中均发现位于表皮细胞间质的抗体。在所有病变中均发现了IgG、IgA和IgM类免疫球蛋白以及C3。未发现与腭黏膜发生反应的抗体。采用间接IF技术检测6例DF患者和10名对照者血清中的循环抗体。以豚鼠唇部及正常口腔黏膜和皮肤作为抗原。所有患者血清及1份对照血清与豚鼠唇部的基底细胞发生反应。3份DF患者血清——但对照血清均未——与人口腔黏膜的基底细胞发生反应。所有血清均未与人体皮肤发生反应。
