α-三氟甲基苯乙烯与硅烷的光氧化还原无金属烯丙基脱氟硅基化反应
Photoredox Metal-Free Allylic Defluorinative Silylation of α-Trifluoromethylstyrenes with Hydrosilanes.
作者信息
Luo Cong, Zhou Yang, Chen Hang, Wang Ting, Zhang Zheng-Bing, Han Pan, Jing Lin-Hai
机构信息
Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China.
出版信息
Org Lett. 2022 Jun 17;24(23):4286-4291. doi: 10.1021/acs.orglett.2c01690. Epub 2022 Jun 8.
We report an efficient strategy that combines organic photoredox and hydrogen atom transfer to deliver difluoroallylsilanes via defluorinative silylation of α-trifluoromethylstyrenes using hydrosilanes as silicon sources. This protocol provides an environmentally friendly approach for the preparation of structurally diverse -difluoroallylsilanes with excellent functional group compatibility and renders it suitable for late-stage modification of bioactive and complex molecules.
我们报道了一种有效的策略，该策略结合了有机光氧化还原和氢原子转移，以硅烷为硅源，通过α-三氟甲基苯乙烯的脱氟硅烷化反应来制备二氟烯丙基硅烷。该方案为制备结构多样的二氟烯丙基硅烷提供了一种环境友好的方法，具有优异的官能团兼容性，适用于生物活性和复杂分子的后期修饰。
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