Lu Xi, Wang Xiao-Xu, Gong Tian-Jun, Pi Jing-Jing, He Shi-Jiang, Fu Yao
Hefei National Laboratory for Physical Sciences at the Microscale , CAS Key Laboratory of Urban Pollutant Conversion , Anhui Province Key Laboratory of Biomass Clean Energy , iChEM , University of Science and Technology of China , Hefei 230026 , China . Email:
Chem Sci. 2018 Nov 7;10(3):809-814. doi: 10.1039/c8sc04335c. eCollection 2019 Jan 21.
Herein, we report a nickel-catalyzed allylic defluorinative alkylation of trifluoromethyl alkenes through reductive decarboxylation of redox-active esters. The present reaction enables the preparation of functionalized -difluoroalkenes with the formation of sterically hindered C(sp)-C(sp) bonds under very mild reaction conditions, while tolerating many sensitive functional groups and requiring minimal substrate protection. Therefore, this method provides an efficient and convenient approach for late-stage modification of biologically interesting molecules.
在此，我们报道了一种通过氧化还原活性酯的还原脱羧实现的镍催化三氟甲基烯烃的烯丙基脱氟烷基化反应。本反应能够在非常温和的反应条件下制备官能化的二氟烯烃，并形成空间位阻较大的C(sp³)-C(sp³)键，同时耐受许多敏感官能团且所需的底物保护最少。因此，该方法为具有生物学意义的分子的后期修饰提供了一种高效便捷的途径。
