Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brasil.
Mem Inst Oswaldo Cruz. 2022 Jun 6;117:e210172. doi: 10.1590/0074-02760210172. eCollection 2022.
In this chapter, the main prognostic markers of Chagas heart disease are addressed, with an emphasis on the most recent findings and questions, establishing the basis for a broad discussion of recommendations and new approaches to managing Chagas cardiopathy. The main biological and genetic markers and the contribution of the electrocardiogram, echocardiogram and cardiac magnetic resonance are presented. We also discuss the most recent therapeutic proposals for heart failure, thromboembolism and arrhythmias, as well as current experience in heart transplantation in patients suffering from severe Chagas cardiomyopathy. The clinical and epidemiological challenges introduced by acute Chagas disease due to oral contamination are discussed. In addition, we highlight the importance of ageing and comorbidities in influencing the outcome of chronic Chagas heart disease. Finally, we discuss the importance of public policies, the vital role of funding agencies, universities, the scientific community and health professionals, and the application of new technologies in finding solutions for better management of Chagas heart disease.
在本章中，我们将讨论恰加斯心脏病的主要预后标志物，并重点介绍最新的发现和问题，为广泛讨论恰加斯心疾病的管理建议和新方法奠定基础。我们介绍了主要的生物学和遗传学标志物以及心电图、超声心动图和心脏磁共振的贡献。我们还讨论了心力衰竭、血栓栓塞和心律失常的最新治疗建议，以及在严重恰加斯心肌病患者中进行心脏移植的现有经验。我们讨论了因口服感染引起的急性恰加斯病带来的临床和流行病学挑战。此外，我们强调了衰老和合并症对慢性恰加斯心脏病结局的影响。最后，我们讨论了公共政策的重要性，资助机构、大学、科学界和卫生专业人员的重要作用，以及新技术在寻找更好管理恰加斯心脏病方法中的应用。
