Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Fundação Oswaldo Cruz, Eusébio, CE, Brazil.
Einstein (Sao Paulo). 2022 Jun 1;20:eAO6959. doi: 10.31744/einstein_journal/2022AO6959. eCollection 2022.
To analyze the effectiveness and safety of two insulin therapy techniques (continuous and intermittent infusion) in the blood glucose control of people who have undergone liver transplantation, in the immediate postoperative period.
The study was a prospective, open, pragmatic clinical trial with 42 participants, divided into two groups of 21 patients each, in the immediate postoperative period following liver transplantation. Participants in the Experimental Group and Control Group received continuous infusion and bolus insulin, respectively, starting at capillary blood glucose ≥150mg/dL.
There were no statistically significant differences in the blood glucose reduction time to reach the target range between the Experimental Group and Control Group in the transplanted patients (p=0.919). No statistically significant differences regarding the presence of low blood glucose (p=0.500) and in the initial blood glucose value (p=0.345) were found. The study identified the final blood glucose value in postoperative intensive care unit lower and statistically significant in the continuous infusion pump group in relation to the Bolus Group (p<0.001). Additionally, the variation of blood glucose reduction was higher and statistically significant in the continuous method group (p<0.05).
The continuous infusion method was more effective in the blood glucose control of patients in the postoperative period following liver transplantation.
RBR-9Y5tbp.
分析两种胰岛素治疗技术（连续输注和间歇输注）在肝移植术后即刻患者血糖控制中的有效性和安全性。
这是一项前瞻性、开放、实用的临床试验，共纳入 42 名参与者，分为两组，每组 21 名患者，均在肝移植术后即刻。实验组和对照组患者分别接受持续输注和推注胰岛素治疗，起始于毛细血管血糖≥150mg/dL。
在移植患者中，实验组和对照组血糖达标时间无统计学差异（p=0.919）。两组间低血糖发生率（p=0.500）和初始血糖值（p=0.345）无统计学差异。研究发现，与推注组相比，持续输注泵组患者在术后重症监护病房的最终血糖值更低且具有统计学意义（p<0.001）。此外，连续输注组的血糖下降幅度更高且具有统计学意义（p<0.05）。
与间歇输注相比，连续输注方法在肝移植术后患者的血糖控制中更有效。
RBR-9Y5tbp。
