School of Humanities, Beijing Dance Academy, 1, Wanshousi Road, Haidian District, Beijing 100081, China.
College of Physical Education and Sports, Beijing Normal University, 19, Xinjiekouwai St, Haidian District, Beijing 100875, China.
An Acad Bras Cienc. 2022 Jun 3;94(2):e20211180. doi: 10.1590/0001-3765202220211180. eCollection 2022.
The purpose of the study is to further explore the combined effects of exercise and sulfur dioxide (SO2) exposure on the cardiovascular function as well as the underlying mechanisms. Rats were randomly divided into 4 groups: rest group (RG), exercise group (EG), SO2 pollution group (SG) and SO2 pollution + exercise group (SEG). Changes of aortic pressure and left ventricular pressure, Ang II concentration, ACE concentration and ACE activity in rats' myocardial tissue were observed. Compared with RG, the systolic blood pressure, pulse pressure, LVSP, +dp/dtmax and -dp/dtmax of EG increased significantly, diastolic blood pressure, resting heart rate and ACE activity decreased significantly; For rats of SG, 4 weeks SO2 exposure increased LVEDP, Ang II concentration, ACE concentration and ACE activity, decreased the +dp/dtmax and -dp/dtmax; For rats of SEG, the systolic blood pressure, pulse pressure, LVSP, +dp/dtmax and -dp/dtmax decreased significantly, HR, LVEDP, Ang II concentration, ACE concentration and ACE activity increased significantly. Results indicate that, the combination of aerobic exercise and SO2 exposure can aggravate the negative effects of SO2 inhalation on cardiovascular function. Renin-angiotensin system plays an important role in mediating the negative effect of SO2 inhalation.
本研究旨在进一步探讨运动和二氧化硫（SO2）暴露对心血管功能的联合影响及其潜在机制。将大鼠随机分为 4 组：休息组（RG）、运动组（EG）、SO2 污染组（SG）和 SO2 污染+运动组（SEG）。观察大鼠主动脉压和左心室压、血管紧张素 II（Ang II）浓度、血管紧张素转换酶（ACE）浓度和 ACE 活性的变化。与 RG 相比，EG 的收缩压、脉压、LVSP、+dp/dtmax 和-dp/dtmax 显著增加，舒张压、静息心率和 ACE 活性显著降低；对于 SG 组大鼠，4 周 SO2 暴露增加 LVEDP、Ang II 浓度、ACE 浓度和 ACE 活性，降低+dp/dtmax 和-dp/dtmax；对于 SEG 组大鼠，收缩压、脉压、LVSP、+dp/dtmax 和-dp/dtmax 显著降低，HR、LVEDP、Ang II 浓度、ACE 浓度和 ACE 活性显著升高。结果表明，有氧运动和 SO2 暴露的结合会加重 SO2 吸入对心血管功能的负面影响。肾素-血管紧张素系统在介导 SO2 吸入的负面效应中起重要作用。
