用脑复新（吡硫醇）治疗后“老年”大鼠大脑中乙酰胆碱浓度的增加。
Increase in acetylcholine concentrations in the brain of 'old' rats following treatment with pyrithioxin (Encephabol).
作者信息
Martin K J, Vyas S
出版信息
Br J Pharmacol. 1987 Mar;90(3):561-5. doi: 10.1111/j.1476-5381.1987.tb11206.x.
Abstract
Treatment of old rats, for two to three weeks, with pyrithioxin led to an increase in the levels of endogenous acetylcholine (ACh) in the cortex and the striatum but not in the hippocampus. Pretreatment of old rats with pyrithioxin also increased the resting release and the K+ stimulated release of radioactive ACh from brain slices in vitro.
摘要
用脑复新对老年大鼠进行两到三周的治疗，可使大脑皮层和纹状体中内源性乙酰胆碱（ACh）水平升高，但海马体中的水平未见升高。用脑复新对老年大鼠进行预处理，还可增加体外脑片放射性ACh的静息释放量以及钾离子刺激后的释放量。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
CNS effects of choline administration: evidence for temporal dependence.胆碱给药对中枢神经系统的影响：时间依赖性证据
Neuropharmacology. 1981 Jun;20(6):535-9. doi: 10.1016/0028-3908(81)90205-7.
3
The cholinergic hypothesis of geriatric memory dysfunction.老年记忆功能障碍的胆碱能假说。
Science. 1982 Jul 30;217(4558):408-14. doi: 10.1126/science.7046051.
4
Application to mammalian tissues of the chemiluminescent method for detecting acetylcholine.化学发光法检测乙酰胆碱在哺乳动物组织中的应用。
J Neurochem. 1982 Jul;39(1):248-50. doi: 10.1111/j.1471-4159.1982.tb04727.x.
5
The pharmacology of memory: a neurobiological perspective.记忆的药理学：神经生物学视角
Annu Rev Pharmacol Toxicol. 1981;21:323-56. doi: 10.1146/annurev.pa.21.040181.001543.
6
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J Neurochem. 1983 Aug;41(2):473-80. doi: 10.1111/j.1471-4159.1983.tb04765.x.
7
Problems in the organization and control of acetylcholine synthesis in brain neurons.脑神经元中乙酰胆碱合成的组织与调控问题。
Prog Biophys Mol Biol. 1984;44(1):1-46. doi: 10.1016/0079-6107(84)90011-7.
8
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