Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener St. 62, 50937 Cologne, Germany.
Institute of Neuroscience and Medicine (INM-3, -4), Research Center Juelich, Juelich, Germany.
Neuro Oncol. 2022 Nov 2;24(11):1815-1826. doi: 10.1093/neuonc/noac131.
Many studies in patients with brain tumors evaluating innovative PET tracers have been published in recent years, and the initial results are promising. Here, the Response Assessment in Neuro-Oncology (RANO) PET working group provides an overview of the literature on novel investigational PET tracers for brain tumor patients. Furthermore, newer indications of more established PET tracers for the evaluation of glucose metabolism, amino acid transport, hypoxia, cell proliferation, and others are also discussed. Based on the preliminary findings, these novel investigational PET tracers should be further evaluated considering their promising potential. In particular, novel PET probes for imaging of translocator protein and somatostatin receptor overexpression as well as for immune system reactions appear to be of additional clinical value for tumor delineation and therapy monitoring. Progress in developing these radiotracers may contribute to improving brain tumor diagnostics and advancing clinical translational research.
近年来,许多评估创新 PET 示踪剂的脑肿瘤患者研究已发表,初步结果令人鼓舞。在这里,神经肿瘤学反应评估 (RANO) PET 工作组提供了脑肿瘤患者新型研究性 PET 示踪剂文献的概述。此外,还讨论了更具开创性的 PET 示踪剂用于评估葡萄糖代谢、氨基酸转运、缺氧、细胞增殖等的新适应症。基于初步研究结果,鉴于这些新型研究性示踪剂具有良好的发展前景,应进一步评估它们的价值。特别是,用于成像转位蛋白和生长抑素受体过表达以及免疫系统反应的新型 PET 探针似乎在肿瘤描绘和治疗监测方面具有额外的临床价值。这些放射性示踪剂的开发进展可能有助于改善脑肿瘤的诊断,并推动临床转化研究的发展。