Key Laboratory of Big Data Mining and Precision Drug Design of Guangdong Medical University, Key Laboratory for Research and Development of Natural Drugs of Guangdong Province, School of Pharmacy, Guangdong Medical University, No. 1 Xincheng Road, Dongguan, 523808, Guangdong, China.
Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, 524023, Guangdong, China.
Mol Biol Rep. 2022 Oct;49(10):9975-9995. doi: 10.1007/s11033-022-07556-1. Epub 2022 Jun 8.
The abnormal expression of nuclear factor kappa B (NF-κB) target genes is closely related to the occurrence, metastasis, and invasion of tumor cells and is an inhibitor of their apoptosis. In recent years, the unique biodiversity in the marine environment has aroused great interest. Many studies indicate that some marine compounds exert anticancer effects on most common human tumors by modulating the NF-κB signaling pathway. In this study, 26 marine compounds that reduce cancer cell survival by suppressing the NF-κB signaling pathway were reviewed. They were derived from a wide range of sources, including sponges, fungi, algae and their derivatives or metabolites. These marine compounds exert antitumor effects through the canonical, noncanonical and atypical NF-κB signaling pathways; however, most of their anticancer targets and mechanisms remain unclear, and more research is needed in the future. Our article provides comprehensive information for researchers investigating the bioactivities of marine compounds and developing marine-derived anticancer drugs.
核因子 kappa B（NF-κB）靶基因的异常表达与肿瘤细胞的发生、转移和浸润密切相关，是其凋亡的抑制剂。近年来，海洋环境中独特的生物多样性引起了极大的兴趣。许多研究表明，一些海洋化合物通过调节 NF-κB 信号通路对大多数常见的人类肿瘤发挥抗癌作用。在这项研究中，综述了 26 种通过抑制 NF-κB 信号通路减少癌细胞存活的海洋化合物。它们来自广泛的来源，包括海绵、真菌、藻类及其衍生物或代谢物。这些海洋化合物通过经典、非经典和非典型 NF-κB 信号通路发挥抗肿瘤作用；然而，它们的大多数抗癌靶点和机制尚不清楚，未来还需要更多的研究。我们的文章为研究海洋化合物生物活性和开发海洋来源抗癌药物的研究人员提供了全面的信息。
