早期乳腺癌中孕激素受体状态的预测能力

Predictive power of progesterone receptor status in early breast carcinoma.

作者信息

Sutton R, Campbell M, Cooke T, Nicholson R, Griffiths K, Taylor I

出版信息

Br J Surg. 1987 Mar;74(3):223-6. doi: 10.1002/bjs.1800740325.

Abstract

Progesterone receptor status (PgR) and oestrogen receptor status (ER) were examined in 332 women with stage I-II breast carcinoma treated at a single centre either by simple mastectomy with (n = 283) or without (n = 6) axillary clearance, or by segmental mastectomy with (n = 18) or without (n = 25) axillary clearance and radiotherapy; median follow-up time was 40 (range 10-60) months. Neither the concentration nor the presence of PgR related to either disease-free interval or survival. However both the presence and the concentration of ER were found to be associated with a longer disease-free interval amongst patients with stage II tumours (P less than 0.01). From this study it appears that progesterone receptor status does not predict outcome in early breast carcinoma.

摘要

对在单一中心接受治疗的332例I-II期乳腺癌女性患者的孕激素受体状态（PgR）和雌激素受体状态（ER）进行了检测。这些患者有的接受单纯乳房切除术，其中进行腋窝清扫的有283例，未进行腋窝清扫的有6例；有的接受乳房部分切除术，其中进行腋窝清扫并接受放疗的有18例，未进行腋窝清扫的有25例。中位随访时间为40（范围10 - 60）个月。PgR的浓度及是否存在均与无病生存期或生存率无关。然而，在II期肿瘤患者中，ER的存在及浓度均与较长的无病生存期相关（P < 0.01）。从这项研究看来，孕激素受体状态不能预测早期乳腺癌的预后。