• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

SARS-CoV-2 Evolution and Immune Escape in Immunocompromised Patients.

作者信息

Scherer Erin M, Babiker Ahmed, Adelman Max W, Allman Brent, Key Autum, Kleinhenz Jennifer M, Langsjoen Rose M, Nguyen Phuong-Vi, Onyechi Ivy, Sherman Jacob D, Simon Trevor W, Soloff Hannah, Tarabay Jessica, Varkey Jay, Webster Andrew S, Weiskopf Daniela, Weissman Daniel B, Xu Yongxian, Waggoner Jesse J, Koelle Katia, Rouphael Nadine, Pouch Stephanie M, Piantadosi Anne

机构信息

Emory University, Atlanta, GA

Emory Healthcare, Atlanta, GA.

出版信息

N Engl J Med. 2022 Jun 23;386(25):2436-2438. doi: 10.1056/NEJMc2202861. Epub 2022 Jun 8.

DOI:10.1056/NEJMc2202861
PMID:35675197
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9202319/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9194/9202319/563fec801901/NEJMc2202861_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9194/9202319/563fec801901/NEJMc2202861_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9194/9202319/563fec801901/NEJMc2202861_f1.jpg

相似文献

1
SARS-CoV-2 Evolution and Immune Escape in Immunocompromised Patients.免疫功能低下患者中SARS-CoV-2的进化与免疫逃逸
N Engl J Med. 2022 Jun 23;386(25):2436-2438. doi: 10.1056/NEJMc2202861. Epub 2022 Jun 8.
2
Antigenic escape is accelerated by the presence of immunocompromised hosts.抗原逃逸是由免疫功能低下宿主的存在加速的。
Proc Biol Sci. 2022 Nov 9;289(1986):20221437. doi: 10.1098/rspb.2022.1437.
3
Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants.COVID-19 患者体内 SARS-CoV-2 的宿主内进化是免疫逃逸变异株的来源。
Nat Commun. 2021 Nov 4;12(1):6405. doi: 10.1038/s41467-021-26602-3.
4
Antigenic drift: Understanding COVID-19.抗原漂移：了解 COVID-19。
Immunity. 2021 Dec 14;54(12):2681-2687. doi: 10.1016/j.immuni.2021.11.016.
5
Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein finds additional vaccine-induced epitopes beyond those for mild infection.全面描述了针对 SARS-CoV-2 刺突蛋白的抗体反应，发现了除轻度感染诱导的表位之外的其他疫苗诱导的表位。
Elife. 2022 Jan 24;11:e73490. doi: 10.7554/eLife.73490.
6
Drastic decline in sera neutralization against SARS-CoV-2 Omicron variant in Wuhan COVID-19 convalescents.武汉新冠肺炎康复者血清对 SARS-CoV-2 奥密克戎变异株的中和能力急剧下降。
Emerg Microbes Infect. 2022 Dec;11(1):567-572. doi: 10.1080/22221751.2022.2031311.
7
Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants.全面绘制 SARS-CoV-2 RBD 特异性中和抗体的结合热点，用于跟踪免疫逃逸变异株。
Genome Med. 2021 Oct 14;13(1):164. doi: 10.1186/s13073-021-00985-w.
8
Viro-immunological evaluation in an immunocompromised patient with long-lasting SARS-CoV-2 infection.对一名患有长期新冠病毒2型（SARS-CoV-2）感染的免疫功能低下患者的病毒免疫学评估。
Emerg Microbes Infect. 2022 Dec;11(1):786-789. doi: 10.1080/22221751.2022.2045877.
9
Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland.爱尔兰免疫功能低下患者体内 SARS-CoV-2 病毒的基因组进化。
Emerg Infect Dis. 2021 Sep;27(9):2499-2501. doi: 10.3201/eid2709.211159. Epub 2021 Jun 23.
10
Monitoring and managing SARS-CoV-2 evolution in immunocompromised populations.监测和管理免疫功能低下人群中新冠病毒的进化
Lancet Microbe. 2022 May;3(5):e325-e326. doi: 10.1016/S2666-5247(22)00061-1. Epub 2022 Mar 15.

引用本文的文献

1
Immune pressure is key to understanding observed patterns of respiratory virus evolution in prolonged infections.免疫压力是理解在长期感染中观察到的呼吸道病毒进化模式的关键。
Virus Evol. 2025 Jul 21;11(1):veaf054. doi: 10.1093/ve/veaf054. eCollection 2025.
2
Within-host bacterial evolution and the emergence of pathogenicity.宿主体内细菌进化与致病性的出现。
Nat Microbiol. 2025 Jul 25. doi: 10.1038/s41564-025-02036-1.
3
In-depth analysis of the risk factors for persistent severe acute respiratory syndrome coronavirus 2 infection and construction of predictive models: an exploratory research study.

本文引用的文献

1
SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape.在晚期 HIV 疾病中，SARS-CoV-2 持续感染会导致广泛的免疫逃逸。
Cell Host Microbe. 2022 Feb 9;30(2):154-162.e5. doi: 10.1016/j.chom.2022.01.005. Epub 2022 Jan 14.
2
COVID-19 in Patients Receiving CD20-depleting Immunochemotherapy for B-cell Lymphoma.接受CD20靶向免疫化疗的B细胞淋巴瘤患者中的新型冠状病毒肺炎
Hemasphere. 2021 Jun 28;5(7):e603. doi: 10.1097/HS9.0000000000000603. eCollection 2021 Jul.
3
Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies.
新型冠状病毒2型持续感染危险因素的深入分析及预测模型构建：一项探索性研究
BMC Infect Dis. 2025 May 14;25(1):699. doi: 10.1186/s12879-025-11083-2.
4
In depth sequencing of a serially sampled household cohort reveals the within-host dynamics of Omicron SARS-CoV-2 and rare selection of novel spike variants.对一个连续采样的家庭队列进行深度测序，揭示了奥密克戎SARS-CoV-2在宿主内的动态变化以及新型刺突变异株的罕见选择。
PLoS Pathog. 2025 Apr 28;21(4):e1013134. doi: 10.1371/journal.ppat.1013134. eCollection 2025 Apr.
5
Quasi-species prevalence and clinical impact of evolving SARS-CoV-2 lineages in European COVID-19 cohorts, January 2020 to February 2022.2020年1月至2022年2月期间，欧洲新冠肺炎队列中不断演变的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）谱系的准种流行情况及临床影响
Euro Surveill. 2025 Mar;30(10). doi: 10.2807/1560-7917.ES.2025.30.10.2400038.
6
Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques.被动输注一种S2茎区广泛中和抗体可保护恒河猴免受SARS-CoV-2感染并减轻下呼吸道炎症。
PLoS Pathog. 2025 Jan 23;21(1):e1012456. doi: 10.1371/journal.ppat.1012456. eCollection 2025 Jan.
7
Virus Evolution in Prolonged Infections of Immunocompromised Individuals.免疫功能低下个体长期感染中的病毒进化
Clin Chem. 2025 Jan 3;71(1):109-118. doi: 10.1093/clinchem/hvae150.
8
The Intestine in Acute and Long COVID: Pathophysiological Insights and Key Lessons.急性和长期新冠中的肠道：病理生理学见解与关键经验教训
Yale J Biol Med. 2024 Dec 19;97(4):447-462. doi: 10.59249/PMIE8461. eCollection 2024 Dec.
9
In depth sequencing of a serially sampled household cohort reveals the within-host dynamics of Omicron SARS-CoV-2 and rare selection of novel spike variants.对一个连续采样的家庭队列进行深度测序，揭示了奥密克戎SARS-CoV-2在宿主内的动态变化以及新型刺突变异株的罕见选择。
bioRxiv. 2024 Nov 22:2024.11.21.624722. doi: 10.1101/2024.11.21.624722.
10
Comment on: Antiviral effect of Evusheld in COVID-19 hospitalized patients infected with pre-Omicron or Omicron variants: a modelling analysis of the randomized DisCoVeRy trial.评论：恩适得对感染奥密克戎变异株之前或奥密克戎变异株的新冠肺炎住院患者的抗病毒作用：随机发现试验的建模分析
J Antimicrob Chemother. 2025 Mar 3;80(3):891-892. doi: 10.1093/jac/dkae385.
全面绘制影响多克隆人血浆抗体识别的 SARS-CoV-2 受体结合域突变图谱。
Cell Host Microbe. 2021 Mar 10;29(3):463-476.e6. doi: 10.1016/j.chom.2021.02.003. Epub 2021 Feb 8.
4
Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape.SARS-CoV-2 刺突糖蛋白的反复缺失可导致抗体逃逸。
Science. 2021 Mar 12;371(6534):1139-1142. doi: 10.1126/science.abf6950. Epub 2021 Feb 3.
5
Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host.严重急性呼吸综合征冠状病毒2型在免疫功能低下宿主中的持续存在与演变
N Engl J Med. 2020 Dec 3;383(23):2291-2293. doi: 10.1056/NEJMc2031364. Epub 2020 Nov 11.