LaVail J H, Koo E H, Dekker N P
Brain Res. 1987 Feb 24;404(1-2):127-32. doi: 10.1016/0006-8993(87)91363-1.
The 'wobbler' mutant mouse can be recognized at about 4 weeks of age by its tremor and atrophy of forelimb muscles. In addition to degeneration of spinal motoneurons, especially in cervical spinal cord, selected bulbar motoneurons have also been reported to degenerate in the mutant. We examined a cranial motor nucleus and found a 31% loss of abducens motoneurons in 4-5-week-old wobbler mice as compared to age-matched control mice.
“摇摆症”突变小鼠在约4周龄时，可通过其震颤和前肢肌肉萎缩被识别出来。除了脊髓运动神经元退化，尤其是颈脊髓中的运动神经元，据报道该突变体中特定的延髓运动神经元也会退化。我们检查了一个颅神经运动核，发现与年龄匹配的对照小鼠相比，4-5周龄的摇摆症小鼠展神经运动神经元损失了31%。
