Blumstein L K, Crawley J N, Davis L G, Baldino F
Brain Res. 1987 Feb 24;404(1-2):293-300. doi: 10.1016/0006-8993(87)91381-3.
The nucleus accumbens contains many neuropeptides whose functions are presently unknown. The purpose of this study was to determine the extent to which these neuropeptides act in conjunction with the mesolimbic dopamine system. Microinjections of cholecystokinin, neurotensin, met-enkephalin, somatostatin, bombesin, as well as glutamate and muscimol, were made into the medial nucleus accumbens after systemic injection of apomorphine. Cholecystokinin and neurotensin, in nanogram doses, potentiated apomorphine-induced stereotypy. Met-enkephalin reduced, while somatostatin and bombesin were without effect on, apomorphine-induced stereotypy. In addition, both glutamate and muscimol potentiated this effect. These results suggest that several neuropeptides and amino acids act in the nucleus accumbens to modulate apomorphine-induced stereotyped behaviors.
伏隔核含有许多目前功能未知的神经肽。本研究的目的是确定这些神经肽与中脑边缘多巴胺系统协同作用的程度。在全身注射阿扑吗啡后，将胆囊收缩素、神经降压素、甲硫氨酸脑啡肽、生长抑素、蛙皮素以及谷氨酸和蝇蕈醇微量注射到伏隔核内侧。纳克剂量的胆囊收缩素和神经降压素增强了阿扑吗啡诱导的刻板行为。甲硫氨酸脑啡肽减少了阿扑吗啡诱导的刻板行为，而生长抑素和蛙皮素则无此作用。此外，谷氨酸和蝇蕈醇都增强了这种作用。这些结果表明，几种神经肽和氨基酸在伏隔核中发挥作用，以调节阿扑吗啡诱导的刻板行为。
