文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Tieppo C A, Nasello A G, Felicio L F

Department of Pathology, School of Veterinary Medicine, University of São Paulo, Brazil.

Prog Neuropsychopharmacol Biol Psychiatry. 1997 May;21(4):683-95. doi: 10.1016/s0278-5846(97)00041-9.

The goal was to verify if central or peripheral sulphated cholecystokinin octapeptide (CCK8) injections can modulate apomorphine (APO)-induced stereotyped behavior. Experiments were designed to determine the involvement of cholecystokinin receptor subtypes as well. 2. Animals which received CCK8 (0.0725, 0.145 and 14.5 nmol, icv) showed a significant (p < 0.05) decrease in APO (0.6 mg/kg, sc)-induced stereotyped behavior. 3. No other statistically significant difference was observed among groups. Since ip CCK8 (1.16 or 2.32 nmol/kg) injections did not interfere with APO-induced stereotypy, the results suggest that the CCK8 modulatory effects have a central action. 4. The results also suggest that the effects of icv CCK8 were not due to the stimulation of CCK8 receptors alone since central CCK4 (14.5 or 29.0 nmol) injections did not interfere with the expression of stereotypy.

目的是验证中枢或外周注射硫酸化胆囊收缩素八肽（CCK8）是否能调节阿扑吗啡（APO）诱导的刻板行为。实验还旨在确定胆囊收缩素受体亚型的参与情况。2. 接受CCK8（0.0725、0.145和14.5纳摩尔，脑室内注射）的动物，其阿扑吗啡（0.6毫克/千克，皮下注射）诱导的刻板行为显著减少（p<0.05）。3. 各实验组之间未观察到其他具有统计学意义的差异。由于腹腔注射CCK8（1.16或2.32纳摩尔/千克）不影响阿扑吗啡诱导的刻板行为，结果表明CCK8的调节作用具有中枢效应。4. 结果还表明，脑室内注射CCK8的效应并非仅由CCK8受体的刺激所致，因为脑室内注射CCK4（14.5或29.0纳摩尔）不影响刻板行为的表现。

Tieppo C A, Nasello A G, Felicio L F

Department of Pathology, School of Veterinary Medicine, University of São Paulo, Brazil.

Prog Neuropsychopharmacol Biol Psychiatry. 1997 May;21(4):683-95. doi: 10.1016/s0278-5846(97)00041-9.

The goal was to verify if central or peripheral sulphated cholecystokinin octapeptide (CCK8) injections can modulate apomorphine (APO)-induced stereotyped behavior. Experiments were designed to determine the involvement of cholecystokinin receptor subtypes as well. 2. Animals which received CCK8 (0.0725, 0.145 and 14.5 nmol, icv) showed a significant (p < 0.05) decrease in APO (0.6 mg/kg, sc)-induced stereotyped behavior. 3. No other statistically significant difference was observed among groups. Since ip CCK8 (1.16 or 2.32 nmol/kg) injections did not interfere with APO-induced stereotypy, the results suggest that the CCK8 modulatory effects have a central action. 4. The results also suggest that the effects of icv CCK8 were not due to the stimulation of CCK8 receptors alone since central CCK4 (14.5 or 29.0 nmol) injections did not interfere with the expression of stereotypy.

目的是验证中枢或外周注射硫酸化胆囊收缩素八肽（CCK8）是否能调节阿扑吗啡（APO）诱导的刻板行为。实验还旨在确定胆囊收缩素受体亚型的参与情况。2. 接受CCK8（0.0725、0.145和14.5纳摩尔，脑室内注射）的动物，其阿扑吗啡（0.6毫克/千克，皮下注射）诱导的刻板行为显著减少（p<0.05）。3. 各实验组之间未观察到其他具有统计学意义的差异。由于腹腔注射CCK8（1.16或2.32纳摩尔/千克）不影响阿扑吗啡诱导的刻板行为，结果表明CCK8的调节作用具有中枢效应。4. 结果还表明，脑室内注射CCK8的效应并非仅由CCK8受体的刺激所致，因为脑室内注射CCK4（14.5或29.0纳摩尔）不影响刻板行为的表现。