Chemical Engineering Program/COPPE, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, Bloco G, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, Brazil.
School of Chemistry, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, Bloco E, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, Brazil.
J Chromatogr A. 2022 Jul 19;1675:463182. doi: 10.1016/j.chroma.2022.463182. Epub 2022 May 31.
The interest in the simulated moving bed (SMB) technology lies in its variants. Some of them that have a high potential to increase the performance in enantioseparations are the ModiCon and the ModiCon+VariCol. These variants are based on the modulation of feed concentration and a combination of feed concentration and length of zones modulations. The concept of the ModiCon process in the literature is that it can be applied only for systems described by nonlinear isotherms. However, there are no numerical or experimental studies that prove that. On the other hand, the hybrid operation of ModiCon+VariCol can be used in systems with a low number of columns due to the flexibility in the use of columns, but it has been little explored. In this work, the maximal performance of the ModiCon process was compared with the SMB process for a linear isotherm. Additionally, the ModiCon+VariCol process was evaluated in systems with a low number of columns. The enantioseparation of guaifenesin was considered as a case study. The result shows that the ModiCon process can also be applied with high performance in systems described by linear isotherms. In the evaluation of the ModiCon+VariCol process for unequal product purity, it was found that the hybrid operation with 3 columns showed a higher throughput and productivity than the SMB process with 6 columns. The productivity of the ModiCon+VariCol was more than three times higher than the conventional operation.
人们对模拟移动床 (SMB) 技术的兴趣在于其变体。其中一些变体在对映体分离方面具有很大的提高性能的潜力，它们是 ModiCon 和 ModiCon+VariCol。这些变体基于进料浓度的调制以及进料浓度和区域长度调制的组合。文献中 ModiCon 工艺的概念是，它只能应用于由非线性等温线描述的系统。然而，没有数值或实验研究证明这一点。另一方面，由于在使用柱子方面具有灵活性，因此 ModiCon+VariCol 的混合操作可以用于柱子数量较少的系统，但这方面的研究还很少。在这项工作中，比较了 ModiCon 过程的最大性能与 SMB 过程在线性等温线系统中的性能。此外，还评估了 ModiCon+VariCol 过程在柱子数量较少的系统中的应用。使用愈创甘油醚作为案例研究来进行对映体分离。结果表明，ModiCon 过程也可以在由线性等温线描述的系统中以高性能应用。在评估 ModiCon+VariCol 过程对于不等产品纯度的情况时，发现具有 3 根柱子的混合操作比具有 6 根柱子的 SMB 过程具有更高的吞吐量和生产率。与传统操作相比，ModiCon+VariCol 的生产率要高三倍以上。
