Pais Luís S, Rodrigues Alírio E
Laboratory of Separation and Reaction Engineering, School of Engineering, University of Porto, Rua Dr. Roberto Frias s/n, 4200-465 Porto, Portugal.
J Chromatogr A. 2003 Jul 18;1006(1-2):33-44. doi: 10.1016/s0021-9673(03)00557-0.
Simulated moving bed (SMB) chromatography has received significant attention in the last decade, particularly as regards the production of very valuable products, such as enantiomerically pure pharmaceutical compounds. Recent applications in the pharmaceutical industry use SMB systems containing a low total number chromatographic columns, usually four to eight. This paper deals with the modeling and simulation of SMB systems with only four, five and six columns. In particular, two modeling strategies, the equivalent true moving bed and the real SMB models, are compared for these units in terms of separation regions and system productivity. Also, the recently proposed Varicol process is analyzed and compared with the classical SMB operation, and the advantages of this new operation mode are shown for systems using a low number of columns.
在过去十年中，模拟移动床（SMB）色谱法受到了广泛关注，特别是在生产非常有价值的产品方面，例如对映体纯的药物化合物。制药行业最近的应用使用的SMB系统色谱柱总数较少，通常为四到八根。本文研究了仅包含四、五和六根色谱柱的SMB系统的建模与模拟。具体而言，针对这些单元，从分离区域和系统生产率方面比较了两种建模策略，即等效真移动床模型和实际SMB模型。此外，还对最近提出的Varicol工艺进行了分析，并与传统的SMB操作进行了比较，展示了这种新操作模式在使用较少色谱柱的系统中的优势。
