Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro Seodaemun-gu, Seoul 120-749, South Korea.
J Chromatogr A. 2013 Oct 11;1311:79-89. doi: 10.1016/j.chroma.2013.08.058. Epub 2013 Aug 21.
The Backfill-SMB (BF-SMB) strategy was designed to improve the separation performance of simulated moving bed (SMB) chromatography. In the BF-SMB operation, a limited amount of products from raffinate and/or extract was re-fed to the SMB circuit as a backfill-feed. Two additional operating variables, backfill ratio (BR) and backfill length (BL), were suggested to determine the amount and injection length of backfill-feed. This strategy was applied to a four-zone SMB with one column (1-1-1-1) and two columns (2-2-2-2) per zone using a binary mixture with a nonlinear isotherm. Various BF-SMB operational methods were designed to supply backfill-feed to the feed node and/or intermediate node. The separation performances of conventional SMB and BF-SMB were compared in terms of purity, recovery, and eluent consumption. The BF-SMB successfully improved the separation performance of the conventional SMB because backfill-feed led to the rich condition of the main component at each product withdrawal node. Due to the 'TMB effect' caused by backfill-feed, the BF-SMB operation was more efficient in the 1-1-1-1 configuration than in the 2-2-2-2 configuration, showing maximum improvement of 5-7% purity and recovery from the performance of conventional SMB. In addition, partial recycling of eluent by backfill-feed resulted in a decrease in eluent consumption up to 10% even with improved purity and recovery in BF-SMB.
尾料- SMB（BF-SMB）策略旨在提高模拟移动床（SMB）色谱的分离性能。在 BF-SMB 操作中，将一定量的来自 raffinate 和/或 extract 的产品作为尾料回注到 SMB 回路中。提出了两个额外的操作变量，即回注比（BR）和回注长度（BL），以确定回注进料的量和注入长度。该策略应用于具有一个柱（1-1-1-1）和每个区两个柱（2-2-2-2）的四区 SMB，使用具有非线性等温线的二元混合物。设计了各种 BF-SMB 操作方法，以便将回注进料供应到进料节点和/或中间节点。从纯度、回收率和洗脱剂消耗等方面比较了常规 SMB 和 BF-SMB 的分离性能。由于回注进料导致每个产品抽出节点的主成分处于丰富状态，BF-SMB 成功地提高了常规 SMB 的分离性能。由于回注进料引起的“TMB 效应”，BF-SMB 操作在 1-1-1-1 配置下比在 2-2-2-2 配置下更有效，显示出从常规 SMB 性能提高 5-7%的纯度和回收率。此外，通过回注进料部分回收洗脱剂，即使在 BF-SMB 中提高了纯度和回收率，洗脱剂消耗仍可降低 10%。
