外泌体 circRNAs 在肿瘤免疫和癌症进展中的作用。
Roles of exosomal circRNAs in tumour immunity and cancer progression.
机构信息
Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Academy of Medical Sciences, Zhengzhou University, Zhengzhou, 450052, Henan, China.
出版信息
Cell Death Dis. 2022 Jun 9;13(6):539. doi: 10.1038/s41419-022-04949-9.
Tumour immunity plays an important role in the development of cancer. Tumour immunotherapy is an important component of antitumour therapy. Exosomes, a type of extracellular vesicle, act as mediators of intercellular communication and molecular transfer and play an essential role in tumour immunity. Circular RNAs (circRNAs) are a new type of noncoding RNA that are enriched within exosomes. In this review, we describe the effects of exosomal circRNAs on various immune cells and the mechanisms of these effects, including macrophages, neutrophils, T cells, and Natural killer (NK) cells. Next, we elaborate on the latest progress of exosome extraction. In addition, the function of exosomal circRNAs as a potential prognostic and drug sensitivity marker is described. We present the great promise of exosomal circRNAs in regulating tumour immunity, predicting patient outcomes, and evaluating drug efficacy.
肿瘤免疫在癌症的发展中起着重要作用。肿瘤免疫疗法是抗肿瘤治疗的重要组成部分。外泌体是一种细胞外囊泡，作为细胞间通讯和分子转移的介质，在肿瘤免疫中起着至关重要的作用。环状 RNA（circRNAs）是一种新型的非编码 RNA，在 exosomes 中富集。在这篇综述中，我们描述了外泌体 circRNAs 对各种免疫细胞的影响及其作用机制，包括巨噬细胞、中性粒细胞、T 细胞和自然杀伤（NK）细胞。接下来，我们详细阐述了外泌体提取的最新进展。此外，还描述了外泌体 circRNAs 作为潜在的预后和药物敏感性标志物的功能。我们展示了外泌体 circRNAs 在调节肿瘤免疫、预测患者预后和评估药物疗效方面的巨大潜力。
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