Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 16666-63111, Iran.
Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran 16666-63111, Iran.
Int J Mol Sci. 2021 Dec 30;23(1):415. doi: 10.3390/ijms23010415.
miR-149 is an miRNA with essential roles in carcinogenesis. This miRNA is encoded by the gene on 2q37.3. The miR-149 hairpin produces miR-149-5p and miR-149-3p, which are the "guide" and the sister "passenger" strands, respectively. Deep sequencing experiments have shown higher prevalence of miR-149-5p compared with miR-149-3p. Notably, both oncogenic and tumor suppressive roles have been reported for miR-149-5p. In this review, we summarize the impact of miR-149-5p in the tumorigenesis and elaborate mechanisms of its involvement in this process in a variety of neoplastic conditions based on three lines of evidence, i.e., in vitro, in vivo and clinical settings.
miR-149 是一种在癌症发生中起重要作用的 miRNA。该 miRNA 由基因编码，位于 2q37.3。miR-149 发夹产生 miR-149-5p 和 miR-149-3p，它们分别是“指导”和“姐妹”的“过客”链。深度测序实验表明，miR-149-5p 的存在频率高于 miR-149-3p。值得注意的是，miR-149-5p 既有致癌作用，也有肿瘤抑制作用。在这篇综述中，我们总结了 miR-149-5p 在肿瘤发生中的作用，并根据三个方面的证据，即体外、体内和临床环境，详细阐述了其参与这一过程的机制。
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