Hall G H, Jones B J, Head A C, Jones V E
Ann Rheum Dis. 1978 Aug;37(4):351-6. doi: 10.1136/ard.37.4.351.
The effects of intra-articular methotrexate (MTX) were compared with saline in 20 patients with persistent knee effusions due to rheumatoid arthritis (15) and psoriasis (5) in a double-blind pilot study. Clinical improvement was seen in most patients given either MTX or saline and was attributed to joint irrigation during arthroscopy and the placebo effects. MTX had a local anti-inflammatory effect in the psoriatic arthropathies; the percentages of polymorphonuclear cells and pyroninophilic mononuclear cells in synovial fluids fell sharply. Intraarticular hydrocortisone acetate was not anti-inflammatory in 2 psoriatic patients treated subsequently. The anti-inflammatory action of MTX in joints may resemble its effectiveness in controlling the rash of psoriasis.
在一项双盲试验研究中，对20例因类风湿性关节炎（15例）和银屑病（5例）导致膝关节持续积液的患者，比较了关节内注射甲氨蝶呤（MTX）与注射生理盐水的效果。接受MTX或生理盐水治疗的大多数患者都有临床改善，这归因于关节镜检查时的关节冲洗和安慰剂效应。MTX在银屑病关节炎中具有局部抗炎作用；滑液中多形核细胞和嗜派洛宁单核细胞的百分比急剧下降。随后接受治疗的2例银屑病患者中，关节内注射醋酸氢化可的松并无抗炎作用。MTX在关节中的抗炎作用可能与其控制银屑病皮疹的效果相似。
