关节内注射甲氨蝶呤。类风湿性关节炎和银屑病关节炎的临床与实验室研究。
Intra-articular methotrexate. Clinical and laboratory study in rheumatoid and psoriatic arthritis.
作者信息
Hall G H, Jones B J, Head A C, Jones V E
出版信息
Ann Rheum Dis. 1978 Aug;37(4):351-6. doi: 10.1136/ard.37.4.351.
Abstract
The effects of intra-articular methotrexate (MTX) were compared with saline in 20 patients with persistent knee effusions due to rheumatoid arthritis (15) and psoriasis (5) in a double-blind pilot study. Clinical improvement was seen in most patients given either MTX or saline and was attributed to joint irrigation during arthroscopy and the placebo effects. MTX had a local anti-inflammatory effect in the psoriatic arthropathies; the percentages of polymorphonuclear cells and pyroninophilic mononuclear cells in synovial fluids fell sharply. Intraarticular hydrocortisone acetate was not anti-inflammatory in 2 psoriatic patients treated subsequently. The anti-inflammatory action of MTX in joints may resemble its effectiveness in controlling the rash of psoriasis.
摘要
在一项双盲试验研究中，对20例因类风湿性关节炎（15例）和银屑病（5例）导致膝关节持续积液的患者，比较了关节内注射甲氨蝶呤（MTX）与注射生理盐水的效果。接受MTX或生理盐水治疗的大多数患者都有临床改善，这归因于关节镜检查时的关节冲洗和安慰剂效应。MTX在银屑病关节炎中具有局部抗炎作用；滑液中多形核细胞和嗜派洛宁单核细胞的百分比急剧下降。随后接受治疗的2例银屑病患者中，关节内注射醋酸氢化可的松并无抗炎作用。MTX在关节中的抗炎作用可能与其控制银屑病皮疹的效果相似。
相似文献
1
Intra-articular methotrexate. Clinical and laboratory study in rheumatoid and psoriatic arthritis.关节内注射甲氨蝶呤。类风湿性关节炎和银屑病关节炎的临床与实验室研究。
Ann Rheum Dis. 1978 Aug;37(4):351-6. doi: 10.1136/ard.37.4.351.
2
Intra-articular methotrexate versus corticosteroid injections in medium-sized joints of rheumatoid arthritis patients-an intervention study.类风湿关节炎患者中关节内甲氨蝶呤与皮质类固醇注射的比较-一项干预研究。
Clin Rheumatol. 2018 Feb;37(2):331-337. doi: 10.1007/s10067-017-3843-y. Epub 2017 Sep 30.
3
Intra-articular methotrexate associated to lipid nanoemulsions: anti-inflammatory effect upon antigen-induced arthritis.关节内甲氨蝶呤联合脂纳米乳液：对抗原诱导关节炎的抗炎作用。
Int J Nanomedicine. 2013;8:443-9. doi: 10.2147/IJN.S29392. Epub 2013 Feb 14.
4
Comparison of intra-articular methotrexate with intra-articular triamcinolone hexacetonide by thermography.
Curr Med Res Opin. 1977;5(2):141-6. doi: 10.1185/03007997709110154.
5
Intra-articular methotrexate in the treatment of rheumatoid arthritis and psoriatic arthritis: a clinical and sonographic study.关节内注射甲氨蝶呤治疗类风湿关节炎和银屑病关节炎：一项临床与超声研究
Clin Rheumatol. 2006 Mar;25(2):159-63. doi: 10.1007/s10067-005-1144-3. Epub 2005 Jun 10.
6
Novel hyaluronic acid-methotrexate conjugate suppresses joint inflammation in the rat knee: efficacy and safety evaluation in two rat arthritis models.新型透明质酸-甲氨蝶呤偶联物可抑制大鼠膝关节炎症：两种大鼠关节炎模型的疗效与安全性评估
Arthritis Res Ther. 2016 Apr 1;18:79. doi: 10.1186/s13075-016-0971-8.
7
Intra-articular treatment of inflammatory arthritis with microsphere formulations of methotrexate: pharmacokinetics and efficacy determination in antigen-induced arthritic rabbits.用甲氨蝶呤微球制剂进行炎性关节炎的关节内治疗：抗原诱导性关节炎兔的药代动力学和疗效测定
Inflamm Res. 2009 Aug;58(8):445-56. doi: 10.1007/s00011-009-0009-7. Epub 2009 Mar 6.
8
Inhibition of interleukin-8 synthesis by intraarticular methotrexate therapy in patients with rheumatoid arthritis.关节内注射甲氨蝶呤治疗类风湿关节炎患者对白细胞介素-8合成的抑制作用。
Z Rheumatol. 1998 Apr;57(2):95-100. doi: 10.1007/s003930050066.
9
Letter: Intra-articular methotrexate.信件：关节腔内注射甲氨蝶呤。
Lancet. 1975 Aug 30;2(7931):409. doi: 10.1016/s0140-6736(75)92925-6.
10
A randomised controlled trial of etanercept and methotrexate to induce remission in early inflammatory arthritis: the EMPIRE trial.依那西普和甲氨蝶呤诱导早期炎症性关节炎缓解的随机对照试验：EMPIRE 试验。
Ann Rheum Dis. 2014 Jun;73(6):1027-36. doi: 10.1136/annrheumdis-2013-204882. Epub 2014 Mar 11.
引用本文的文献
1
Targeted nanoliposomes for precision rheumatoid arthritis therapy: a review on mechanisms and potential.用于精准类风湿性关节炎治疗的靶向纳米脂质体：作用机制与潜力综述
Drug Deliv. 2025 Dec;32(1):2459772. doi: 10.1080/10717544.2025.2459772. Epub 2025 Feb 1.
2
Intra-articular therapy with methotrexate or tumor necrosis factor inhibitors in rheumatoid arthritis: a systematic review.类风湿关节炎中使用甲氨蝶呤或肿瘤坏死因子抑制剂的关节内治疗：一项系统评价
BMC Musculoskelet Disord. 2021 Sep 15;22(1):792. doi: 10.1186/s12891-021-04651-5.
3
Safety of Intra-articular Methotrexate Injection With and Without Electroporation for Inflammatory Small Joints in Patients With Rheumatoid Arthritis.类风湿关节炎患者炎症性小关节关节腔内注射甲氨蝶呤（无论是否联合电穿孔）的安全性
Clin Med Insights Arthritis Musculoskelet Disord. 2019 Nov 4;12:1179544119886303. doi: 10.1177/1179544119886303. eCollection 2019.
4
Methotrexate for psoriatic arthritis.甲氨蝶呤用于治疗银屑病关节炎。
Cochrane Database Syst Rev. 2019 Jan 18;1(1):CD012722. doi: 10.1002/14651858.CD012722.pub2.
5
Intra-articular methotrexate versus corticosteroid injections in medium-sized joints of rheumatoid arthritis patients-an intervention study.类风湿关节炎患者中关节内甲氨蝶呤与皮质类固醇注射的比较-一项干预研究。
Clin Rheumatol. 2018 Feb;37(2):331-337. doi: 10.1007/s10067-017-3843-y. Epub 2017 Sep 30.
6
[A history of joint puncture and injection].[关节穿刺及注射史]
Z Rheumatol. 2011 Jan;70(1):69-78. doi: 10.1007/s00393-010-0737-7.
7
Intra-articular methotrexate in the treatment of rheumatoid arthritis and psoriatic arthritis: a clinical and sonographic study.关节内注射甲氨蝶呤治疗类风湿关节炎和银屑病关节炎：一项临床与超声研究
Clin Rheumatol. 2006 Mar;25(2):159-63. doi: 10.1007/s10067-005-1144-3. Epub 2005 Jun 10.
8
A risk-benefit assessment of intra-articular corticosteroids in rheumatic disorders.风湿性疾病中关节腔内注射皮质类固醇的风险效益评估。
Drug Saf. 1999 Nov;21(5):353-65. doi: 10.2165/00002018-199921050-00002.
9
Rheumatoid knee synovitis successfully treated with intra-articular rifamycin SV.关节腔内注射利福霉素SV成功治疗类风湿性膝关节滑膜炎
Ann Rheum Dis. 1982 Jun;41(3):232-6. doi: 10.1136/ard.41.3.232.
10
Antirheumatic drug concentrations in human synovial fluid and synovial tissue. Observations on extravascular pharmacokinetics.人体滑液和滑膜组织中的抗风湿药物浓度。关于血管外药代动力学的观察。
Clin Pharmacokinet. 1983 Nov-Dec;8(6):496-522. doi: 10.2165/00003088-198308060-00002.
本文引用的文献
1
SYNOVIAL LINING CELLS AND PLASMA CELLS IN THE SYNOVIAL MEMBRANE IN CASES OF CLASSIC RHEUMATOID ARTHRITIS. A STUDY BASED PARTLY ON HISTOLOGICAL SECTIONS STAINED BY THE METHYL GREEN-PYRONINE METHOD.典型类风湿性关节炎病例中滑膜的滑膜衬里细胞和浆细胞。一项部分基于用甲基绿-派洛宁法染色的组织学切片的研究。
Acta Rheumatol Scand. 1965;11:4-14. doi: 10.3109/rhe1.1965.11.issue-1-4.01.
2
METHOTREXATE THERAPY IN PSORIATIC ARTHRITIS; DOUBLE-BLIND STUDY ON 21 PATIENTS.甲氨蝶呤治疗银屑病关节炎；21例患者的双盲研究。
JAMA. 1964 Sep 7;189:743-7.
3
Synovial cells. A study of the morphology and an examination of protein synthesis of synovial cells.滑膜细胞。滑膜细胞的形态学研究及蛋白质合成检测。
Ann Rheum Dis. 1966 Nov;25(6):534-46. doi: 10.1136/ard.25.6.534.
4
Effects of intra-articular corticosteroids in vivo on synovial fluid variables in rheumatoid synovitis.关节内注射皮质类固醇对类风湿性滑膜炎患者滑液变量的体内影响。
Ann Rheum Dis. 1974 Jan;33(1):62-6. doi: 10.1136/ard.33.1.62.
5
Relation of cellular infiltration of rheumatoid synovial membrane to its immune response.类风湿性滑膜的细胞浸润与其免疫反应的关系。
Arthritis Rheum. 1974 May-Jun;17(3):313-9. doi: 10.1002/art.1780170317.
6
Chemical action and pharmacology of methotrexate, azathioprine and cyclophosphamide in man.甲氨蝶呤、硫唑嘌呤和环磷酰胺在人体中的化学作用及药理学
Arthritis Rheum. 1973 Jan-Feb;16(1):79-83. doi: 10.1002/art.1780160113.
7
8
Routine assay for detection of IgG and IgM antiglobulins in seronegative and seropositive rheumatoid arthritis.血清阴性和血清阳性类风湿性关节炎中IgG和IgM抗球蛋白检测的常规测定
Br Med J. 1975 Jul 26;3(5977):203-4. doi: 10.1136/bmj.3.5977.203.
9
Methotrexate.甲氨蝶呤
Ann Intern Med. 1977 Feb;86(2):199-204. doi: 10.7326/0003-4819-86-2-199.
10
The clinical pharmacology of antineoplastic agents (first of two parts).
N Engl J Med. 1975 May 22;292(21):1107-13. doi: 10.1056/NEJM197505222922107.
Zotero 插件