INSERM U976, Université Paris Cité, Paris, France.
Curr Stem Cell Res Ther. 2023;18(1):54-61. doi: 10.2174/1574888X17666220608101852.
Tumor recurrence is a colossal challenge in clinical oncology. This multifactorial problem is attributed to the emergence of additional genetic mutations and the presence of dormant cancer cells. However, the plasticity of non-stem cancer cells and the acquisition of cancer stem cell (CSC) functionality is another contributing factor to tumor recurrence. Herein, I focus attention on the mechanisms that fuel cancer cell de-differentiation and the interplay between intra-cellular regulators and tumor microenvironment (TME) landscape that promotes cancer cell stemness. Our understanding of the mechanisms underlying tumor cell de-differentiation is crucial for developing innovative therapeutic strategies that prevent cancer from ever recurring.
肿瘤复发是临床肿瘤学面临的巨大挑战。这个多因素问题归因于额外基因突变的出现和休眠癌细胞的存在。然而，非干细胞癌细胞的可塑性和获得癌症干细胞（CSC）功能也是肿瘤复发的另一个因素。在此，我重点关注促进癌细胞去分化的机制以及细胞内调节剂和肿瘤微环境（TME）景观之间的相互作用，这些相互作用促进了癌细胞的干性。我们对肿瘤细胞去分化背后机制的理解对于开发创新性治疗策略以防止癌症复发至关重要。
