Service of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.
Front Immunol. 2022 May 23;13:899161. doi: 10.3389/fimmu.2022.899161. eCollection 2022.
infects the gastric mucosa of a large number of humans. Although asymptomatic in the vast majority of cases, infection can lead to the development of peptic ulcers gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. Using a variety of mechanisms, locally suppresses the function of the host immune system to establish chronic infection. Systemic immunomodulation has been observed in both clinical and pre-clinical studies, which have demonstrated that infection is associated with reduced incidence of inflammatory diseases, such as asthma and Crohn's disease. The introduction of immunotherapies in the arsenal of anti-cancer drugs has revealed a new facet of -induced immune suppression. In this review, we will describe the intimate interactions between and its host, and formulate hypothtyeses describing the detrimental impact of infection on the efficacy of cancer immunotherapies.
感染大量人类的胃黏膜。尽管在绝大多数情况下无症状，但感染可导致消化性溃疡、胃腺癌和黏膜相关淋巴组织（MALT）淋巴瘤的发生。通过多种机制，局部抑制宿主免疫系统的功能以建立慢性感染。临床和临床前研究均观察到系统免疫调节，表明感染与炎症性疾病（如哮喘和克罗恩病）发生率降低有关。免疫疗法在抗癌药物武器库中的引入揭示了 - 诱导免疫抑制的新方面。在这篇综述中，我们将描述与宿主之间的密切相互作用，并提出描述感染对癌症免疫疗法疗效的不利影响的假设。
