Department of Hematology and Rheumatology, Faculty of Medicine Kindai University, Osaka Sayama, Osaka, Japan.
Department of Hematology and Rheumatology, Faculty of Medicine Kindai University, Osaka Sayama, Osaka, Japan.
Cancer Lett. 2018 Feb 1;414:147-152. doi: 10.1016/j.canlet.2017.11.009. Epub 2017 Nov 11.
The complex diversity of nonpathogenic microbes that colonize the human body, known as microbiota, exert considerable effects on physiological homeostasis, and immune regulation. Helicobacter pylori (H. pylori) is a bacterium that frequently colonizes human stomach and is a major pathogenic agent for peptic ulcer diseases, gastric cancer, and mucosa-associated lymphoid tissue (MALT) lymphoma. Due to its acidic pH and peristaltic movements, the stomach has been considered a hostile environment for most microorganisms, however various commensal microorganisms are capable of colonizing the stomach to form a stomach niche. Recent pieces of evidence indicate that commensal gastric microbes or their metabolites influence the capability of H. pylori to colonize the stomach and directly modulate its pathogenicity and carcinogenic potential. In this article, we present an overview of recent advances in the understanding of H. pylori-commensal interactions in the pathogenesis and clinical evolution of H. pylori-associated gastric malignancies.
定植于人体的无致病微生物（即微生物群）具有复杂多样的特性，对生理稳态和免疫调节有重要影响。幽门螺杆菌（H. pylori）是一种定植于人类胃部的细菌，是消化性溃疡病、胃癌和黏膜相关淋巴组织（MALT）淋巴瘤的主要致病因子。由于胃部的酸性 pH 值和蠕动，胃被认为是大多数微生物的恶劣环境，但各种共生微生物能够定植于胃，形成胃小生境。最近的证据表明，共生胃微生物或其代谢产物影响 H. pylori 定植胃的能力，并直接调节其致病性和致癌潜能。本文综述了 H. pylori 与共生菌相互作用在 H. pylori 相关胃部恶性肿瘤发病机制和临床演变中的最新研究进展。
