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脐带间充质干细胞改善大鼠卵巢早衰

Umbilical Cord Mesenchymal Stem Cells Ameliorate Premature Ovarian Insufficiency in Rats.

作者信息

Zhang Meiliang, Xie Tingting, Dai Weiyou, Zhao Bo, Zheng Yaqin, Hu Jianmiao, Pan Ruolang, Wang Liang

机构信息

Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Department of Obstetrics and Gynecology, Yiwu Maternity and Children Hospital, Yiwu Branch of Children's Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China.

出版信息

Evid Based Complement Alternat Med. 2022 May 30;2022:9228456. doi: 10.1155/2022/9228456. eCollection 2022.

DOI:10.1155/2022/9228456
PMID:35677383
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9170415/
Abstract

Premature ovarian insufficiency (POI) or premature ovarian failure (POF) is known as a state of hypergonadotropic hypogonadism. Stem cell therapy is expected to be used in the treatment of POI. The aim of the present study was to explore the feasibility and effectiveness of umbilical cord mesenchymal stem cell (UCMSC) transplantation for the treatment of POI in a rat model of POI induced by cyclophosphamide (CTX) injection. The ovarian function was examined by evaluating the weight of the ovary and body, estrus cycle, ovarian morphology, hormonal secretion, granulosa cell apoptosis, and fertility. The results showed that the ovarian function indicators of the modeled rats were comparable to those of the control rats after UCMSC transplantation, indicating that the ovarian function of the modeled rats recovered to a satisfactory extent. Our research may provide an experimental clue for the clinical application of UCMSC transplantation in the treatment of POI. Further experiments will focus on the detailed signaling pathway study of the molecular mechanisms of injury and repairment on the treatment with UCMSCs transplantation in the rat POI models.

摘要

卵巢早衰（POI）或卵巢早绝经（POF）被认为是一种高促性腺激素性性腺功能减退状态。干细胞疗法有望用于治疗POI。本研究的目的是探讨在环磷酰胺（CTX）注射诱导的POI大鼠模型中，脐带间充质干细胞（UCMSC）移植治疗POI的可行性和有效性。通过评估卵巢和身体重量、发情周期、卵巢形态、激素分泌、颗粒细胞凋亡和生育能力来检测卵巢功能。结果表明，UCMSC移植后，模型大鼠的卵巢功能指标与对照大鼠相当，表明模型大鼠的卵巢功能恢复到了令人满意的程度。我们的研究可能为UCMSC移植治疗POI的临床应用提供实验线索。进一步的实验将集中于对大鼠POI模型中UCMSC移植治疗损伤和修复分子机制的详细信号通路研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0de4/9170415/92d23a30edb5/ECAM2022-9228456.008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0de4/9170415/d41b59b5ccb4/ECAM2022-9228456.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0de4/9170415/92d23a30edb5/ECAM2022-9228456.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0de4/9170415/5b47c7917de8/ECAM2022-9228456.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0de4/9170415/b43b4a93a320/ECAM2022-9228456.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0de4/9170415/be78e9b16f60/ECAM2022-9228456.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0de4/9170415/6139c18467bf/ECAM2022-9228456.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0de4/9170415/ff61467263da/ECAM2022-9228456.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0de4/9170415/9f96bc880d30/ECAM2022-9228456.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0de4/9170415/d41b59b5ccb4/ECAM2022-9228456.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0de4/9170415/92d23a30edb5/ECAM2022-9228456.008.jpg

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