Wu Diana, Taibi Amel, Lin Zhen, Thompson Lilian U, Comelli Elena M
Department of Nutritional Sciences, University of Toronto, ON, Canada.
Joannah and Brian Lawson Centre for Child Nutrition, University of Toronto, ON, Canada.
Data Brief. 2022 May 29;42:108328. doi: 10.1016/j.dib.2022.108328. eCollection 2022 Jun.
Dietary flaxseed may act via microRNAs (miRNAs) to affect the health of the mammary gland. These data are in support of the article entitled "Effects of flaxseed and its components on mammary gland miRNome: identification of potential biomarkers to prevent breast cancer development" [1]. Here, we provide miRNA expression data obtained from NanoString nCounter® profiling of mammary gland RNA from C57BL/6 female mice who received a control diet or isocaloric diets containing 10% FS, 3.67% FSO, or 0.15% SDG for 21 days. The raw miRNA data were deposited at the NCBI Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE193847) under the accession number GSE193847. We also identified diet-associated miRNA-gene targets and corresponding enriched pathways. These data can be found at the HARVARD Dataverse (https://doi.org/10.7910/DVN/3ZNYES). These data will be valuable as a reference to understand the effects of FS versus its components and to study responses to these ingredients in hosts of different genetic backgrounds, sex and age. These data will contribute to future investigations regarding mechanisms underlying FS effects within the mammary gland.
膳食亚麻籽可能通过微小RNA（miRNA）发挥作用，影响乳腺健康。这些数据支持了题为《亚麻籽及其成分对乳腺微小RNA组的影响：预防乳腺癌发展的潜在生物标志物的鉴定》的文章[1]。在此，我们提供了通过NanoString nCounter®对来自C57BL/6雌性小鼠乳腺RNA进行分析获得的miRNA表达数据，这些小鼠接受了对照饮食或含10%FS、3.67%FSO或0.15%SDG的等热量饮食，持续21天。原始miRNA数据已存入NCBI基因表达综合数据库（GEO）（https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE193847），登录号为GSE193847。我们还鉴定了与饮食相关的miRNA-基因靶点及相应的富集通路。这些数据可在哈佛数据文库（https://doi.org/10.7910/DVN/3ZNYES）中找到。这些数据对于理解FS及其成分的影响以及研究不同遗传背景、性别和年龄宿主对这些成分的反应具有重要参考价值。这些数据将有助于未来对FS在乳腺内作用机制的研究。
