Lee Kee Tat, Misron Nurul Akmar, Abdul Aziz Norasmidar, Wong Chin Hau, Liew Hong Keng
Department of Medicine, Hospital Sultanah Bahiyah, Langgar, Kedah, Malaysia.
Department of Pathology, Hospital Sultanah Bahiyah, Langgar, Kedah, Malaysia.
Case Rep Hematol. 2022 May 30;2022:1142049. doi: 10.1155/2022/1142049. eCollection 2022.
Plasmablastic lymphoma (PBL) is a rare and highly aggressive type of lymphoma, which is commonly associated with human immunodeficiency virus (HIV) infection. Spontaneous regression of aggressive lymphomas is rare as they typically require administration of chemotherapy and radiotherapy for treatment. Here, we describe a case of a spontaneous regression of PBL after nasal biopsy and computed tomography (CT) guided biopsy of paravertebral mass in an immunocompetent patient. We postulate that the patient's immune system may be activated as a result of the stress and physical trauma brought on by nasal and paravertebral mass biopsy. Our case highlights the rare phenomenon of spontaneous regression of lymphoma which needs to be further studied on to establish its underlying pathophysiology.
浆母细胞性淋巴瘤（PBL）是一种罕见且侵袭性很强的淋巴瘤类型，通常与人类免疫缺陷病毒（HIV）感染有关。侵袭性淋巴瘤的自发消退很少见，因为它们通常需要进行化疗和放疗来治疗。在此，我们描述了一例免疫功能正常的患者在鼻活检及计算机断层扫描（CT）引导下对椎旁肿块进行活检后，其PBL自发消退的病例。我们推测，患者的免疫系统可能因鼻及椎旁肿块活检带来的应激和身体创伤而被激活。我们的病例突出了淋巴瘤自发消退这一罕见现象，需要进一步研究以确定其潜在的病理生理学机制。
