Igawa Takuro, Sato Yasuharu, Kawai Hotaka, Kondo Eisei, Takeuchi Mai, Miyata-Takata Tomoko, Takata Katsuyoshi, Yoshino Tadashi
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Division of Pathophysiology, Okayama University Graduate School of Health Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.
Diagn Pathol. 2015 Oct 6;10:183. doi: 10.1186/s13000-015-0421-y.
Plasmablastic lymphoma (PBL) is an aggressive lymphoma commonly associated with human immunodeficiency virus (HIV) infection. Herein we describe a rare case of PBL that spontaneously regressed. An 80-year-old man was referred to our hospital owing to an exophytic gingival tumor in the right maxillary second molar region. He had no significant past medical history, and a screening test for HIV was negative. Imaging showed that the tumor measured 26 × 23 × 16 mm and was confined in the alveolar bone. The tumor was histologically comprised of highly proliferative immunoblastic cells positive for CD138 and Epstein-Barr virus (EBV)-encoded RNA. Monoclonal IgH chain gene rearrangement was detected via polymerase chain reaction. After biopsy and diagnosis of PBL, the tumor began to decrease in size and had apparently disappeared at the time of surgery. There was no histological evidence of a residual lesion in the surgical specimen. In conclusion, a minority of immunosenescence-associated PBLs in the elderly should be recognized as a unique clinicopathological entity distinct from common aggressive PBL.
浆母细胞淋巴瘤（PBL）是一种侵袭性淋巴瘤，通常与人类免疫缺陷病毒（HIV）感染相关。在此，我们描述了一例罕见的自发消退的PBL病例。一名80岁男性因右上颌第二磨牙区域的外生性牙龈肿瘤被转诊至我院。他既往无重大病史，HIV筛查试验为阴性。影像学检查显示肿瘤大小为26×23×16mm，局限于牙槽骨。肿瘤组织学上由CD138和爱泼斯坦-巴尔病毒（EBV）编码RNA阳性的高度增殖免疫母细胞组成。通过聚合酶链反应检测到单克隆IgH链基因重排。活检诊断为PBL后，肿瘤开始缩小，手术时明显消失。手术标本中没有残留病变的组织学证据。总之，老年人群中少数与免疫衰老相关的PBL应被视为一种独特的临床病理实体，有别于常见的侵袭性PBL。
