甲型肝炎疫苗接种后发生的重度儿童类天疱疮样扁平苔藓。
Severe childhood lichen planus pemphigoides after hepatitis A vaccination.
作者信息
Lahouel M, Aounallah A, Mokni S, Sriha B, Belajouza C, Denguezli M
机构信息
Department of Dermatology Farhat Hached Hospital of Sousse Sousse Tunisia.
Department of Pathology Farhat Hached Hospital of Sousse Sousse Tunisia.
出版信息
Skin Health Dis. 2022 Jan 19;2(2):e94. doi: 10.1002/ski2.94. eCollection 2022 Jun.
BACKGROUND
Lichen planus (LP) pemphigoides (LPP) is a very rare autoimmune bullous disorder, that is, exceptional in children.
CASE REPORT
We report a case of LP pemphigoides with severe cutaneous and mucosal involvement in an 8-year-old girl who consulted for multiple vesicular and bullous lesions associated with shiny erythematous-purple plaques. The eruption occurred 2 months after vaccination against hepatitis A virus. The diagnosis of LP pemphigoides was confirmed by histopathology and immunofluorescence examination. The patient received oral corticosteroid therapy with rapid improvement.
CONCLUSION
To our knowledge, this is the first report of LPP following hepatitis A vaccination, among adults and children.
背景
扁平苔藓类天疱疮（LPP）是一种非常罕见的自身免疫性大疱性疾病，在儿童中尤为罕见。
病例报告
我们报告一例8岁女孩患扁平苔藓类天疱疮，有严重的皮肤和黏膜受累，该女孩因多个水疱和大疱性皮损伴发亮的红斑-紫色斑块前来就诊。皮疹在接种甲型肝炎病毒疫苗2个月后出现。扁平苔藓类天疱疮的诊断通过组织病理学和免疫荧光检查得以证实。患者接受口服糖皮质激素治疗后迅速好转。
结论
据我们所知，这是成人和儿童中接种甲型肝炎疫苗后发生扁平苔藓类天疱疮的首例报告。
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