Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, Korea.
J Prev Med Public Health. 2022 May;55(3):234-242. doi: 10.3961/jpmph.22.020. Epub 2022 May 12.
This study assessed the validity and reliability of the Health-related Quality of Life Instrument with 8 Items (HINT-8) in patients with diabetes. HINT-8 is a newly-developed, generic health-related quality of life (HRQoL) instrument.
Three HRQoL instruments-HINT-8, EuroQoL 5-Dimension 5-Level (EQ-5D-5L), and Short Form Health Survey version 2.0 (SF-36v2)-were provided to 300 patients with diabetes visiting a tertiary hospital for follow-up visits in Korea. The HRQoL scores obtained using the HINT-8 were evaluated for subgroups with known differences based on demographics and diabetes-related characteristics (known-group validity). The mean scores of the instruments were compared between groups segmented by their responses to the HINT-8 (discriminatory ability). Correlation coefficients of the HINT-8 with other instruments were calculated (convergent and divergent validity). The Cohen kappa and intra-class correlation coefficient (ICC) were also evaluated (test-retest reliability).
The average HINT-8 indexes were lower among women, older, and less-educated subjects. Subjects who did not list any problems on the HINT-8 had significantly higher HRQoL scores than those who did. The correlation coefficients of the HINT-8 with the EQ-5D-5L index and EuroQoL visual analogue scale were 0.715 (p<0.001) and 0.517 (p<0.001), respectively. The correlation coefficients between the HINT-8 index and the scores of 8 domains of the SF-36v2 ranged from 0.478 (p<0.001) to 0.669 (p<0.001). The Cohen kappa values for the HINT-8 ranged from 0.268 to 0.601, and the ICC of the HINT-8 index was 0.800 (95% confidence interval [CI], 0.720 to 0.860).
This study showed that the HINT-8 is a valid and reliable HRQoL instrument for patients with diabetes.
本研究评估了新开发的通用健康相关生活质量（HRQoL）量表——8 项健康相关生活质量量表（HINT-8）在糖尿病患者中的有效性和可靠性。
300 名在韩国一家三级医院就诊的糖尿病患者接受了 HINT-8、欧洲五维健康量表 5 维度 5 水平（EQ-5D-5L）和健康调查简表 2.0 版本（SF-36v2）这三种 HRQoL 量表的评估。根据人口统计学和糖尿病相关特征（已知组有效性），对 HINT-8 获得的 HRQoL 评分进行亚组评估。根据对 HINT-8 的回答进行分组，比较工具的平均评分（鉴别能力）。计算 HINT-8 与其他工具的相关系数（聚合和发散有效性）。评估 HINT-8 的 Cohen kappa 和组内相关系数（ICC）（重测信度）。
女性、年龄较大和受教育程度较低的患者平均 HINT-8 指数较低。在 HINT-8 上未列出任何问题的患者的 HRQoL 评分显著高于列出问题的患者。HINT-8 与 EQ-5D-5L 指数和欧洲五维健康量表视觉模拟评分的相关系数分别为 0.715（p<0.001）和 0.517（p<0.001）。HINT-8 指数与 SF-36v2 的 8 个领域评分的相关系数范围为 0.478（p<0.001）至 0.669（p<0.001）。HINT-8 的 Cohen kappa 值范围为 0.268 至 0.601，HINT-8 指数的 ICC 为 0.800（95%置信区间[CI]：0.720 至 0.860）。
本研究表明，HINT-8 是一种适用于糖尿病患者的有效且可靠的 HRQoL 工具。
