Zhao Huijie, Liu Huiyang, Yang Yihan, Wang Honggang
Institute of Chronic Disease Risks Assessment, Henan University, Kaifeng 475004, China.
School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
Curr Issues Mol Biol. 2022 May 23;44(5):2362-2373. doi: 10.3390/cimb44050161.
Antrodia cinnamomea is a traditional plant and a unique fungus native to Taiwan that has been reported to have many biological functions, including anti-inflammatory and anticancer activities. The compound 4-acetylarylquinolinol B (4-AAQB) is one of the main bioactive compounds in the stamens of Antrodia cinnamomea, and has many biological functions, such as anti-inflammatory, antiproliferative, blood sugar reduction, antimetastasis, and vascular tone relaxation. In recent years, the increasing evidences have shown that 4-AAQB is involved in many diseases; however, the relevant mechanisms have not been fully clarified. This review aimed to clarify the improvement by 4-AAQB in different pathological processes, as well as the compound's molecular mechanisms, in order to provide a theoretical reference for future related research.
樟芝是一种传统植物，也是台湾特有的真菌，据报道具有多种生物学功能，包括抗炎和抗癌活性。化合物4-乙酰芳基喹啉醇B（4-AAQB）是樟芝雄蕊中的主要生物活性化合物之一，具有多种生物学功能，如抗炎、抗增殖、降血糖、抗转移和血管张力松弛。近年来，越来越多的证据表明4-AAQB与多种疾病有关；然而，相关机制尚未完全阐明。本综述旨在阐明4-AAQB在不同病理过程中的改善作用及其分子机制，为未来相关研究提供理论参考。
