胶质母细胞瘤：代谢与免疫抑制微环境的关系。
Glioblastoma: Relationship between Metabolism and Immunosuppressive Microenvironment.
机构信息
B·ARGO (Badalona Applied Research Group of Oncology) Medical Oncology Department, Catalan Institute of Oncology Badalona, 08916 Badalona, Spain.
Pathology Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
出版信息
Cells. 2021 Dec 14;10(12):3529. doi: 10.3390/cells10123529.
Glioblastoma (GBM) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping this tumor microenvironment (TME) regulate tumor initiation, progression, and treatment response. Genetic alterations and metabolism pathways are two main elements that influence tumor immune cells and TME. In this manuscript, we review how both factors can contribute to an immunosuppressive state and overview the strategies being tested.
胶质母细胞瘤（GBM）是成人中最具侵袭性的脑肿瘤，其特征是免疫抑制微环境。不同的因素塑造了这个肿瘤微环境（TME），调节着肿瘤的发生、进展和治疗反应。遗传改变和代谢途径是影响肿瘤免疫细胞和 TME 的两个主要因素。在本文中，我们回顾了这两个因素如何导致免疫抑制状态，并概述了正在测试的策略。
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