Horsman D E, Pantzar J T, Dill F J, Kalousek D K
Cancer Genet Cytogenet. 1987 Jun;26(2):375-6. doi: 10.1016/0165-4608(87)90073-2.
Klinefelter's syndrome is associated with an increased risk of certain types of cancer. A small number of reports have documented the occurrence of acute leukemia in these patients. Our review of 1200 consecutive patients investigated cytogenetically for actual or suspected hematologic malignancy revealed only one patient with acute leukemia and the 47,XXY syndrome. This finding suggests that the risk of acute leukemia in Klinefelter's patients is no greater than that of the general population.
克兰费尔特综合征与某些类型癌症的风险增加有关。少数报告记录了这些患者中急性白血病的发生情况。我们对1200例因实际或疑似血液系统恶性肿瘤而接受细胞遗传学检查的连续患者进行的回顾显示,仅有1例患有急性白血病且患有47,XXY综合征。这一发现表明,克兰费尔特综合征患者患急性白血病的风险并不高于普通人群。