采用分位数回归分析方法，研究产前氧化应激生物标志物与 ASD 相关结局之间的关联。
Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression.
机构信息
A.J. Drexel Autism Institute, Drexel University, 3020 Market Street, Suite 560, Philadelphia, PA, 19104, United States.
Arkansas Children's Hospital Research Institute, 13 Childrens Way, Little Rock, AR, 72202, United States.
出版信息
J Autism Dev Disord. 2023 Aug;53(8):2975-2985. doi: 10.1007/s10803-022-05625-9. Epub 2022 Jun 9.
Abstract
We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling's childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile β: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers.
摘要
我们研究了产前氧化应激（OS）与儿童自闭症相关结局之间的关系。对自闭症儿童的母亲进行了后续妊娠和其年幼子女童年时期的随访。使用分位数回归来研究谷胱甘肽（GSH）、谷胱甘肽二硫化物（GSSG）、8-氧代-脱氧鸟嘌呤（8-OHdG）和硝基酪氨酸与年幼子女社会反应量表（SRS）评分之间的关系。GSH：GSSG 的增加（表明 OS 降低）与 SRS 评分的轻微增加相关（第 50 百分位数 β：1.78，95%CI：0.67，3.06）；未观察到其他关联。来自自闭症风险增加的队列的结果并不支持妊娠晚期 OS 与自闭症相关结局之间的强关系。结果可能特定于那些具有丰富自闭症风险的人群；未来的工作应该考虑其他时间点和生物标志物。
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