A.J. Drexel Autism Institute, Drexel University, 3020 Market Street, Suite 560, Philadelphia, PA, 19104, United States.
Arkansas Children's Hospital Research Institute, 13 Childrens Way, Little Rock, AR, 72202, United States.
J Autism Dev Disord. 2023 Aug;53(8):2975-2985. doi: 10.1007/s10803-022-05625-9. Epub 2022 Jun 9.
We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling's childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile β: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers.
我们研究了产前氧化应激（OS）与儿童自闭症相关结局之间的关系。对自闭症儿童的母亲进行了后续妊娠和其年幼子女童年时期的随访。使用分位数回归来研究谷胱甘肽（GSH）、谷胱甘肽二硫化物（GSSG）、8-氧代-脱氧鸟嘌呤（8-OHdG）和硝基酪氨酸与年幼子女社会反应量表（SRS）评分之间的关系。GSH：GSSG 的增加（表明 OS 降低）与 SRS 评分的轻微增加相关（第 50 百分位数 β：1.78，95%CI：0.67，3.06）；未观察到其他关联。来自自闭症风险增加的队列的结果并不支持妊娠晚期 OS 与自闭症相关结局之间的强关系。结果可能特定于那些具有丰富自闭症风险的人群；未来的工作应该考虑其他时间点和生物标志物。
