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铜纳米网抗菌第二层皮肤。

Antimicrobial second skin using copper nanomesh.

机构信息

Department of Electrical Engineering and Information Systems, The University of Tokyo, Bunkyo-Ku, Tokyo 113-8656, Japan.

Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, South Korea.

出版信息

Proc Natl Acad Sci U S A. 2022 Jun 14;119(24):e2200830119. doi: 10.1073/pnas.2200830119. Epub 2022 Jun 9.

Abstract

The functional support and advancement of our body while preserving inherent naturalness is one of the ultimate goals of bioengineering. Skin protection against infectious pathogens is an application that requires common and long-term wear without discomfort or distortion of the skin functions. However, no antimicrobial method has been introduced to prevent cross-infection while preserving intrinsic skin conditions. Here, we propose an antimicrobial skin protection platform copper nanomesh, which prevents cross-infectionmorphology, temperature change rate, and skin humidity. Copper nanomesh exhibited an inactivation rate of 99.99% for bacteria and influenza virus A within 1 and 10 min, respectively. The thin and porous nanomesh allows for conformal coating on the fingertips, without significant interference with the rate of skin temperature change and humidity. Efficient cross-infection prevention and thermal transfer of copper nanomesh were demonstrated using direct on-hand experiments.

摘要

在保持内在自然性的同时为身体提供功能性支持和促进,是生物工程的最终目标之一。皮肤作为人体的第一道防线,需要能够抵抗传染性病原体,同时还要能够长期舒适贴合地穿戴,不能对皮肤功能造成任何不适或扭曲。然而,目前还没有引入任何一种既能预防交叉感染又能保持皮肤固有状态的抗菌方法。在这里,我们提出了一种抗菌皮肤保护平台——铜纳米网,它可以防止交叉感染,同时保持皮肤的形态、温度变化率和湿度。铜纳米网在 1 分钟和 10 分钟内分别对细菌和甲型流感病毒的灭活率达到了 99.99%。这种薄而多孔的纳米网可以在指尖上进行贴合涂层,对皮肤温度变化和湿度的速率几乎没有显著干扰。通过直接在手实验,证明了铜纳米网具有高效的交叉感染预防和热传递功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f3d/9214522/b4c6f7cab4f3/pnas.2200830119fig01.jpg

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