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探索植物源生物活性物质作为抗糖尿病药物:一篇广泛的综述。

Exploring the plant-derived bioactive substances as antidiabetic agent: An extensive review.

机构信息

Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh.

Faculty of Medicine and Pharmacy, University of Oradea, P-ta 1 Decembrie 10, 410087 Oradea, Romania.

出版信息

Biomed Pharmacother. 2022 Aug;152:113217. doi: 10.1016/j.biopha.2022.113217. Epub 2022 Jun 6.

Abstract

Diabetes mellitus (DM) is a metabolic syndrome. Diabetes has become more common in recent years. Chemically generated drugs are used to lessen the effects of DM and its following repercussions due to unpleasant side effects such as weight gain, gastrointestinal issues, and heart failure. On the other hand, medicinal plants could be a good source of anti-diabetic medications. This article aims to determine any plant matrix's positive potential. Food restriction, physical activity, and the use of antidiabetic plant-derived chemicals are all being promoted as effective ways to manage diabetes because they are less expensive and have fewer or no side effects. This review focuses on antidiabetic plants, along with their bioactive constituent, chemically characterization, and plant-based diets for diabetes management. There is minimal scientific data about the mechanism of action of the plant-based product has been found. The purpose of this article is to highlight anti-diabetic plants and plant-derived bioactive compounds that have anti-diabetic properties. It also provides researchers with data that may be used to build future strategies, such as identifying promising bioactive molecules to make diabetes management easier.

摘要

糖尿病(DM)是一种代谢综合征。近年来,糖尿病的发病率越来越高。由于体重增加、胃肠道问题和心力衰竭等不良反应,化学合成药物被用于减轻 DM 及其后续影响。另一方面,药用植物可能是抗糖尿病药物的良好来源。本文旨在确定任何植物基质的积极潜力。饮食限制、体育活动和使用源自抗糖尿病植物的化学物质都被认为是管理糖尿病的有效方法,因为它们更便宜,副作用更少或没有。本综述重点介绍了具有抗糖尿病作用的植物及其生物活性成分、化学表征以及用于糖尿病管理的植物性饮食。关于植物性产品的作用机制的科学数据很少。本文的目的是强调具有抗糖尿病特性的植物和植物源性生物活性化合物。它还为研究人员提供了可能用于构建未来策略的数据,例如识别有前途的生物活性分子,以更轻松地管理糖尿病。

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