Tao Dong-Lian, Deng Shan, Hu Yue, Wu Xiu-Quan, Chen Yi-Jian
Gannan Medical College, The First Affiliated Hospital of Gannan Medical College, Ganzhou 341000, Jiangxi Province, China.
Department of Hematology, The First Affiliated Hospital of Gannan Medical College, Ganzhou 341000, Jiangxi Province, China,E-mail：
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2022 Jun;30(3):975-978. doi: 10.19746/j.cnki.issn.1009-2137.2022.03.051.
Exosomes are subtypes of extracellur vesicles containing a variety of cell-specific proteins, lipids and nucleic acids released during cell activation or apoptosis, and play the role of intercellur communication mediators in different physiological and pathological processes. With the development of research in recent years, the role of platelet-derived exosomes in cardiovascular diseases has attracted extensive attention. This paper reviews the role of platelet-derived exosomes in atherosclerotic thrombosis and the potential role of platelet-derived exosomes as biomarkers for the diagnosis and treatment of atherosclerotic thrombotic disease and the problems to be solved.
外泌体是细胞外囊泡的亚型，包含在细胞活化或凋亡过程中释放的多种细胞特异性蛋白质、脂质和核酸，并在不同的生理和病理过程中充当细胞间通讯介质的角色。近年来，随着研究的发展，血小板衍生外泌体在心血管疾病中的作用引起了广泛关注。本文综述了血小板衍生外泌体在动脉粥样硬化血栓形成中的作用，以及血小板衍生外泌体作为动脉粥样硬化血栓性疾病诊断和治疗生物标志物的潜在作用和有待解决的问题。
