Department of Hypertension, Henan Provincial People's Hospital, Laboratory of Cancer Biomarkers and Liquid Biopsy, Henan University, Kaifeng, Henan Province, 475004, China.
Laboratory of Cancer Biomarkers and Liquid Biopsy, Henan University, Kaifeng, Henan Province, 475004, China.
J Cardiovasc Transl Res. 2019 Feb;12(1):68-74. doi: 10.1007/s12265-018-9796-y. Epub 2018 May 25.
Exosomes are now accepted as potential biomarkers in cardiovascular disease development, especially in atherosclerosis. Atherosclerosis is a leading cause of cardiovascular disease-related death and morbidity, accounting for one-fifth of all deaths globally. Therefore, the biomarkers for the management of atherosclerosis is urgently needed. Exosomes are reported to play key roles cell-to-cell communication in atherosclerosis with lipid bilayer membranous vesicles containing nucleic acids, proteins, and lipid contents, which are released from all most of multiple kinds of living cells. This review aims to discuss the potential roles of exosome-derived miRNA, protein, and DNA as biomarkers in atherosclerosis pathogenesis, diagnosis, and therapy.
外泌体现在被认为是心血管疾病发展，尤其是动脉粥样硬化的潜在生物标志物。动脉粥样硬化是心血管疾病相关死亡和发病的主要原因，占全球所有死亡人数的五分之一。因此，迫切需要用于动脉粥样硬化管理的生物标志物。有报道称，外泌体在动脉粥样硬化的细胞间通讯中发挥关键作用，其含有核酸、蛋白质和脂类的脂质双层膜囊泡，由多种活细胞释放。本综述旨在讨论外泌体衍生的 miRNA、蛋白质和 DNA 作为动脉粥样硬化发病机制、诊断和治疗的生物标志物的潜在作用。
